Detailed information of TA system TA184492

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2202811..2203073
• Replicon: chromosome
• Accession: NZ_CP066492
• Organism: Staphylococcus aureus strain nan_175_F371_ch

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: JF380_RS11055
• Protein ID: WP_001802298.1
• Coordinates: 2202969..2203073 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	2202811..2202974 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JF380_RS11035	2199051..2199716	-	666	WP_001024095.1	SDR family oxidoreductase	-
JF380_RS11040	2199868..2200188	+	321	WP_000003755.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
JF380_RS11045	2200190..2201170	+	981	WP_198914115.1	cation diffusion facilitator family transporter	-
JF380_RS11050	2201436..2202527	+	1092	WP_000495681.1	hypothetical protein	-
-	2202811..2202974	+	164	-	-	Antitoxin
JF380_RS11055	2202969..2203073	-	105	WP_001802298.1	hypothetical protein	Toxin
JF380_RS11060	2203753..2203911	+	159	WP_001792784.1	hypothetical protein	-
JF380_RS11065	2204569..2205426	-	858	WP_000370928.1	Cof-type HAD-IIB family hydrolase	-
JF380_RS11070	2205494..2206276	-	783	WP_000908189.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T184492 WP_001802298.1 NZ_CP066492:c2203073-2202969 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T184492 NZ_CP087670:c116838-116356 [Klebsiella pneumoniae]
ATGGGAATGAGAGCGCCTGAATCCCTGACGGCTGAACATAACATCGCTGAGTTCTGCTGCCAGGAGCCTGCCCTTAATGA
GTGGTTAAAGAAGAAGGCTCTCAGAAACCACAGTACCGGCATTTCCCGTGTCTATGTCGTCTGCGCAGAAAACACTAACC
GGGTCATCGGTTATTATTGTTTATCTTCGGGTAGCGTCCACCGTAACACAGTGCCTGGGGCCTATAGACGCAACGCGCCT
GATGTCATTCCAGTCATTGTTTTGGGACGGCTTGCCATCGACCAGGCCTGGGCCGGGAATGGGCTTGGTGCCGCACTTCT
TAAGGATGCTATATACCGTACGCAAAACATAGCCTTTCAGGTCGGGGTGAGAGCACTGGCCGTGCATGCGCTGAATGAAG
AAGTTAAATGTTTTTACACCCGTTTTGGCTTTGAGCCTTCCATAGTCAACACGCTGACATTGTTATTCCCGATAAAAGTC
TGA

Antitoxin

Nucleotide

• Length: 164 bp

>AT184492 NZ_CP066492:2202811-2202974 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin