Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2535935..2536458 Replicon chromosome
Accession NZ_CP066488
Organism Staphylococcus aureus strain ncr_155_F133

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag JF379_RS12675 Protein ID WP_000074048.1
Coordinates 2535935..2536201 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag JF379_RS12680 Protein ID WP_000587616.1
Coordinates 2536201..2536458 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JF379_RS12655 2531241..2532428 - 1188 WP_000026194.1 MFS transporter -
JF379_RS12660 2532824..2533600 - 777 WP_000072145.1 iron export ABC transporter permease subunit FetB -
JF379_RS12665 2533593..2534255 - 663 WP_000923523.1 ATP-binding cassette domain-containing protein -
JF379_RS12670 2534503..2535579 - 1077 WP_001076671.1 M42 family metallopeptidase -
JF379_RS12675 2535935..2536201 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
JF379_RS12680 2536201..2536458 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JF379_RS12685 2536817..2537272 + 456 WP_000732082.1 DUF1307 domain-containing protein -
JF379_RS12690 2537440..2539017 - 1578 WP_198917930.1 FMN-binding glutamate synthase family protein -
JF379_RS12695 2539213..2539962 + 750 WP_000072445.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T184481 WP_000074048.1 NZ_CP066488:c2536201-2535935 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T184481 NZ_CP087669:1911251-1911353 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT184481 WP_000587616.1 NZ_CP066488:c2536458-2536201 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT184481 NZ_CP087669:c1911360-1911215 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References