Detailed information of TA system TA184479

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2504745..2504929
• Replicon: chromosome
• Accession: NZ_CP066488
• Organism: Staphylococcus aureus strain ncr_155_F133

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: JF379_RS12535
• Protein ID: WP_000482647.1
• Coordinates: 2504822..2504929 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2504745..2504805 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JF379_RS12520	2500219..2500386	-	168	WP_001790576.1	hypothetical protein	-
JF379_RS12525	2500617..2502350	-	1734	WP_000486494.1	ABC transporter ATP-binding protein/permease	-
JF379_RS12530	2502375..2504138	-	1764	WP_001064816.1	ABC transporter ATP-binding protein/permease	-
-	2504745..2504805	+	61	-	-	Antitoxin
JF379_RS12535	2504822..2504929	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
JF379_RS12540	2505063..2505449	-	387	WP_000779360.1	flippase GtxA	-
JF379_RS12545	2505707..2506849	+	1143	WP_001176871.1	glycerate kinase	-
JF379_RS12550	2506909..2507568	+	660	WP_000831301.1	membrane protein	-
JF379_RS12555	2507750..2508961	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
JF379_RS12560	2509084..2509557	-	474	WP_000456497.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T184479 WP_000482647.1 NZ_CP066488:c2504929-2504822 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T184479 NZ_CP087669:729762-730247 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT184479 NZ_CP066488:2504745-2504805 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin