184478

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2479388..2479905 Replicon chromosome
Accession NZ_CP066488
Organism Staphylococcus aureus strain ncr_155_F133

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag JF379_RS12400 Protein ID WP_000113262.1
Coordinates 2479388..2479654 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag JF379_RS12405 Protein ID WP_000584499.1
Coordinates 2479654..2479905 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JF379_RS12375 2474813..2475340 - 528 WP_000973468.1 GNAT family N-acetyltransferase -
JF379_RS12380 2475584..2476408 - 825 WP_000572040.1 formate/nitrite transporter family protein -
JF379_RS12385 2476625..2476807 - 183 WP_000230294.1 hypothetical protein -
JF379_RS12390 2476891..2477358 - 468 WP_000153344.1 SRPBCC domain-containing protein -
JF379_RS12395 2477544..2479094 - 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
JF379_RS12400 2479388..2479654 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
JF379_RS12405 2479654..2479905 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JF379_RS12410 2480070..2480171 - 102 Protein_2399 hypothetical protein -
JF379_RS12415 2480178..2480777 - 600 WP_000162810.1 DsbA family protein -
JF379_RS12420 2480796..2481158 - 363 WP_000819843.1 DUF4467 domain-containing protein -
JF379_RS12425 2481413..2482663 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
JF379_RS12430 2482760..2483491 - 732 WP_000615458.1 amino acid ABC transporter ATP-binding protein -
JF379_RS12435 2483488..2484207 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T184478 WP_000113262.1 NZ_CP066488:c2479654-2479388 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T184478 NZ_CP087669:350624-350971 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT184478 WP_000584499.1 NZ_CP066488:c2479905-2479654 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT184478 NZ_CP087669:350971-351270 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATGGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References