Detailed information of TA system TA184469

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1889170..1889352
• Replicon: chromosome
• Accession: NZ_CP066488
• Organism: Staphylococcus aureus strain ncr_155_F133

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: JF379_RS09135
• Protein ID: WP_001801861.1
• Coordinates: 1889170..1889265 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1889293..1889352 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JF379_RS09100	1884840..1885466	+	627	WP_000669017.1	hypothetical protein	-
JF379_RS09105	1885507..1885848	+	342	WP_000627541.1	DUF3969 family protein	-
JF379_RS09110	1885949..1886521	+	573	WP_000414202.1	hypothetical protein	-
JF379_RS09115	1886719..1887276	-	558	Protein_1793	ImmA/IrrE family metallo-endopeptidase	-
JF379_RS09120	1887650..1887826	-	177	WP_000375477.1	hypothetical protein	-
JF379_RS09125	1887837..1888220	-	384	WP_000070811.1	hypothetical protein	-
JF379_RS09130	1888824..1888967	-	144	WP_001549059.1	transposase	-
JF379_RS09135	1889170..1889265	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1889293..1889352	-	60	-	-	Antitoxin
JF379_RS09140	1889388..1889489	+	102	WP_001791893.1	hypothetical protein	-
JF379_RS09145	1889467..1889643	-	177	Protein_1799	transposase	-
JF379_RS09150	1889837..1890214	-	378	WP_001037045.1	DUF1433 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA	1882282..1990177	107895

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T184469 WP_001801861.1 NZ_CP066488:1889170-1889265 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T184469 NZ_CP087663:c5358453-5358070 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Nucleotide

• Length: 60 bp

>AT184469 NZ_CP066488:c1889352-1889293 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin