Detailed information of TA system TA184445

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Txe-Axe/Txe-RelB
• Location: 37144..37663
• Replicon: plasmid p83_44kb
• Accession: NZ_CP066454
• Organism: Enterococcus faecium strain Dallas 83

Toxin (Protein)

• Gene name: Txe
• Uniprot ID: Q848U6
• Locus tag: JCP60_RS15245
• Protein ID: WP_000588503.1
• Coordinates: 37406..37663 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: Axe
• Uniprot ID: Q83WJ8
• Locus tag: JCP60_RS15240
• Protein ID: WP_000388479.1
• Coordinates: 37144..37413 (+)
• Length: 90 a.a.

Genomic Context

Location: 32416..33893 (1478 bp)
Type: Others
Protein ID: Protein_36

Location: 35887..36453 (567 bp)
Type: Others
Protein ID: Protein_39

Location: 36834..37013 (180 bp)
Type: Others
Protein ID: WP_001120991.1

Location: 37144..37413 (270 bp)
Type: Antitoxin
Protein ID: WP_000388479.1

Location: 37406..37663 (258 bp)
Type: Toxin
Protein ID: WP_000588503.1

Location: 38122..39126 (1005 bp)
Type: Others
Protein ID: WP_000455809.1

Location: 40355..41680 (1326 bp)
Type: Others
Protein ID: WP_000969590.1

Location: 41673..42023 (351 bp)
Type: Others
Protein ID: WP_000568378.1

Location: 42020..42199 (180 bp)
Type: Others
Protein ID: WP_001021554.1

Location: 42335..42625 (291 bp)
Type: Others
Protein ID: WP_000026576.1

Location: 33916..34596 (681 bp)
Type: Others
Protein ID: WP_001015311.1

Location: 35131..35811 (681 bp)
Type: Others
Protein ID: WP_002287920.1

Location: 39291..39905 (615 bp)
Type: Others
Protein ID: WP_001261742.1

Loading, please wait

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JCP60_RS15215	32416..33893	+	1478	Protein_36	type I restriction-modification system subunit M	-
JCP60_RS15220	33916..34596	-	681	WP_001015311.1	IS6-like element IS1216 family transposase	-
JCP60_RS15225	35131..35811	-	681	WP_002287920.1	IS6-like element IS1216 family transposase	-
JCP60_RS15230	35887..36453	+	567	Protein_39	hypothetical protein	-
JCP60_RS15235	36834..37013	+	180	WP_001120991.1	hypothetical protein	-
JCP60_RS15240	37144..37413	+	270	WP_000388479.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JCP60_RS15245	37406..37663	+	258	WP_000588503.1	Txe/YoeB family addiction module toxin	Toxin
JCP60_RS15250	38122..39126	+	1005	WP_000455809.1	hypothetical protein	-
JCP60_RS15255	39291..39905	-	615	WP_001261742.1	recombinase family protein	-
JCP60_RS15260	40355..41680	+	1326	WP_000969590.1	Y-family DNA polymerase	-
JCP60_RS15265	41673..42023	+	351	WP_000568378.1	hypothetical protein	-
JCP60_RS15270	42020..42199	+	180	WP_001021554.1	hypothetical protein	-
JCP60_RS15275	42335..42625	+	291	WP_000026576.1	hypothetical protein	-

Associated MGEs

Loading, please wait

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_014959 Enterococcus faecium Non-Mobilizable plasmid TA006115 1..39032 0.009	inside	Non-Mobilizable plasmid	erm(B) / ant(6)-Ia / aph(3')-III / VanHAX	-	1..44442	44442

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10206.53 Da
• Isoelectric Point: 8.4369

>T184445 WP_000588503.1 NZ_CP066454:37406-37663 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Nucleotide

• Length: 258 bp

>T184445 NZ_CP087657:744556-745041 [Klebsiella pneumoniae subsp. pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10373.51 Da
• Isoelectric Point: 4.4346

>AT184445 WP_000388479.1 NZ_CP066454:37144-37413 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Nucleotide

• Length: 270 bp

>AT184445 NZ_CP087657:744266-744559 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Toxin

Loading, please wait

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
No matching records found

Showing 1 to 0 of 0 rows

10

rows per page

• ‹
• ›

Antitoxin

Loading, please wait

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
No matching records found

Showing 1 to 0 of 0 rows

10

rows per page

• ‹
• ›

Structures

Toxin

Loading, please wait

• AlphaFold DB: A0A828ZXQ8

Antitoxin

Loading, please wait

• AlphaFold DB: A0A828ZWU7