Detailed information of TA system TA184439

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Txe-Axe/Txe-RelB
• Location: 37122..37641
• Replicon: plasmid p71_2_44kb
• Accession: NZ_CP066446
• Organism: Enterococcus faecium strain Dallas 71_2

Toxin (Protein)

• Gene name: Txe
• Uniprot ID: Q848U6
• Locus tag: JCP66_RS15690
• Protein ID: WP_000588503.1
• Coordinates: 37384..37641 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: Axe
• Uniprot ID: Q83WJ8
• Locus tag: JCP66_RS15685
• Protein ID: WP_000388479.1
• Coordinates: 37122..37391 (+)
• Length: 90 a.a.

Genomic Context

Location: 32416..33893 (1478 bp)
Type: Others
Protein ID: Protein_36

Location: 35865..36431 (567 bp)
Type: Others
Protein ID: Protein_39

Location: 36812..36991 (180 bp)
Type: Others
Protein ID: WP_001120991.1

Location: 37122..37391 (270 bp)
Type: Antitoxin
Protein ID: WP_000388479.1

Location: 37384..37641 (258 bp)
Type: Toxin
Protein ID: WP_000588503.1

Location: 38100..39104 (1005 bp)
Type: Others
Protein ID: WP_000455809.1

Location: 40333..41658 (1326 bp)
Type: Others
Protein ID: WP_000969590.1

Location: 41651..42001 (351 bp)
Type: Others
Protein ID: WP_000568378.1

Location: 41998..42177 (180 bp)
Type: Others
Protein ID: WP_001021554.1

Location: 42313..42603 (291 bp)
Type: Others
Protein ID: WP_000026576.1

Location: 33916..34596 (681 bp)
Type: Others
Protein ID: WP_001015311.1

Location: 35109..35789 (681 bp)
Type: Others
Protein ID: WP_002287920.1

Location: 39269..39883 (615 bp)
Type: Others
Protein ID: WP_001261742.1

Loading, please wait

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JCP66_RS15660	32416..33893	+	1478	Protein_36	type I restriction-modification system subunit M	-
JCP66_RS15665	33916..34596	-	681	WP_001015311.1	IS6-like element IS1216 family transposase	-
JCP66_RS15670	35109..35789	-	681	WP_002287920.1	IS6-like element IS1216 family transposase	-
JCP66_RS15675	35865..36431	+	567	Protein_39	hypothetical protein	-
JCP66_RS15680	36812..36991	+	180	WP_001120991.1	hypothetical protein	-
JCP66_RS15685	37122..37391	+	270	WP_000388479.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JCP66_RS15690	37384..37641	+	258	WP_000588503.1	Txe/YoeB family addiction module toxin	Toxin
JCP66_RS15695	38100..39104	+	1005	WP_000455809.1	hypothetical protein	-
JCP66_RS15700	39269..39883	-	615	WP_001261742.1	recombinase family protein	-
JCP66_RS15705	40333..41658	+	1326	WP_000969590.1	Y-family DNA polymerase	-
JCP66_RS15710	41651..42001	+	351	WP_000568378.1	hypothetical protein	-
JCP66_RS15715	41998..42177	+	180	WP_001021554.1	hypothetical protein	-
JCP66_RS15720	42313..42603	+	291	WP_000026576.1	hypothetical protein	-

Associated MGEs

Loading, please wait

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_014959 Enterococcus faecium Non-Mobilizable plasmid TA006115 1..39032 0.009	inside	Non-Mobilizable plasmid	erm(B) / ant(6)-Ia / aph(3')-III / VanHAX	-	1..44420	44420

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10206.53 Da
• Isoelectric Point: 8.4369

>T184439 WP_000588503.1 NZ_CP066446:37384-37641 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Nucleotide

• Length: 258 bp

>T184439 NZ_CP087652:c145558-145115 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAACAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
TGGGCACGCTATCGCGGCCGGCGCCGTCCTAGTGACGAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGAAAGCCGCTCTCTGCAGGGTAATTTCTTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10373.51 Da
• Isoelectric Point: 4.4346

>AT184439 WP_000388479.1 NZ_CP066446:37122-37391 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Nucleotide

• Length: 270 bp

>AT184439 NZ_CP087652:c145785-145555 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGCTCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Toxin

Loading, please wait

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
No matching records found

Showing 1 to 0 of 0 rows

10

rows per page

• ‹
• ›

Antitoxin

Loading, please wait

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
No matching records found

Showing 1 to 0 of 0 rows

10

rows per page

• ‹
• ›

Structures

Toxin

Loading, please wait

• AlphaFold DB: A0A828ZXQ8

Antitoxin

Loading, please wait

• AlphaFold DB: A0A828ZWU7