184432

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 31075..31594 Replicon plasmid p66_38kb
Accession NZ_CP066438
Organism Enterococcus faecium strain Dallas 66

Toxin (Protein)


Gene name Txe Uniprot ID Q848U6
Locus tag JCP89_RS15725 Protein ID WP_000588503.1
Coordinates 31337..31594 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID Q83WJ8
Locus tag JCP89_RS15720 Protein ID WP_000388479.1
Coordinates 31075..31344 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JCP89_RS15695 26346..27791 + 1446 Protein_30 type I restriction-modification system subunit M -
JCP89_RS15700 27847..28527 - 681 WP_001015311.1 IS6-like element IS1216 family transposase -
JCP89_RS15705 29062..29742 - 681 WP_002287920.1 IS6-like element IS1216 family transposase -
JCP89_RS15710 29818..30384 + 567 Protein_33 hypothetical protein -
JCP89_RS15715 30765..30944 + 180 WP_001120991.1 hypothetical protein -
JCP89_RS15720 31075..31344 + 270 WP_000388479.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JCP89_RS15725 31337..31594 + 258 WP_000588503.1 Txe/YoeB family addiction module toxin Toxin
JCP89_RS15730 32053..33057 + 1005 WP_000455809.1 hypothetical protein -
JCP89_RS15735 33222..33836 - 615 WP_001261742.1 recombinase family protein -
JCP89_RS15740 34286..35611 + 1326 WP_000969590.1 Y-family DNA polymerase -
JCP89_RS15745 35604..35954 + 351 WP_000568378.1 hypothetical protein -
JCP89_RS15750 35951..36130 + 180 WP_001021554.1 hypothetical protein -
JCP89_RS15755 36266..36556 + 291 WP_000026576.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Non-Mobilizable plasmid erm(B) / ant(6)-Ia / aph(3')-III / VanHAX - 1..38373 38373


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.53 Da        Isoelectric Point: 8.4369

>T184432 WP_000588503.1 NZ_CP066438:31337-31594 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

>T184432 NZ_CP087651:4195742-4195960 [Klebsiella pneumoniae subsp. pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10373.51 Da        Isoelectric Point: 4.4346

>AT184432 WP_000388479.1 NZ_CP066438:31075-31344 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Download         Length: 270 bp

>AT184432 NZ_CP087651:4195341-4195715 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZWU7

References