Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 37123..37642 Replicon plasmid p57_44kb
Accession NZ_CP066429
Organism Enterococcus faecium strain Dallas 57

Toxin (Protein)


Gene name Txe Uniprot ID Q848U6
Locus tag JCP98_RS15115 Protein ID WP_000588503.1
Coordinates 37385..37642 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID Q83WJ8
Locus tag JCP98_RS15110 Protein ID WP_000388479.1
Coordinates 37123..37392 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JCP98_RS15085 32417..33894 + 1478 Protein_36 type I restriction-modification system subunit M -
JCP98_RS15090 33917..34597 - 681 WP_001015311.1 IS6-like element IS1216 family transposase -
JCP98_RS15095 35110..35790 - 681 WP_002287920.1 IS6-like element IS1216 family transposase -
JCP98_RS15100 35866..36432 + 567 Protein_39 hypothetical protein -
JCP98_RS15105 36813..36992 + 180 WP_001120991.1 hypothetical protein -
JCP98_RS15110 37123..37392 + 270 WP_000388479.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JCP98_RS15115 37385..37642 + 258 WP_000588503.1 Txe/YoeB family addiction module toxin Toxin
JCP98_RS15120 38101..39105 + 1005 WP_000455809.1 hypothetical protein -
JCP98_RS15125 39270..39884 - 615 WP_001261742.1 recombinase family protein -
JCP98_RS15130 40334..41659 + 1326 WP_000969590.1 Y-family DNA polymerase -
JCP98_RS15135 41652..42002 + 351 WP_000568378.1 hypothetical protein -
JCP98_RS15140 41999..42178 + 180 WP_001021554.1 hypothetical protein -
JCP98_RS15145 42314..42604 + 291 WP_000026576.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Non-Mobilizable plasmid erm(B) / ant(6)-Ia / aph(3')-III / VanHAX - 1..44421 44421


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.53 Da        Isoelectric Point: 8.4369

>T184423 WP_000588503.1 NZ_CP066429:37385-37642 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

>T184423 NZ_CP087647:c104846-104430 [Klebsiella pneumoniae subsp. pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10373.51 Da        Isoelectric Point: 4.4346

>AT184423 WP_000388479.1 NZ_CP066429:37123-37392 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Download         Length: 270 bp

>AT184423 NZ_CP087647:c105073-104843 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZWU7

References