Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 32620..33139 Replicon plasmid p16_1_41kb
Accession NZ_CP066385
Organism Enterococcus faecium strain Dallas 16_1

Toxin (Protein)


Gene name Txe Uniprot ID Q848U6
Locus tag JCP87_RS16080 Protein ID WP_000588503.1
Coordinates 32882..33139 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID Q83WJ8
Locus tag JCP87_RS16075 Protein ID WP_000388479.1
Coordinates 32620..32889 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JCP87_RS16040 28191..28607 - 417 WP_001232859.1 hypothetical protein -
JCP87_RS16045 28610..28894 - 285 WP_000353844.1 hypothetical protein -
JCP87_RS16050 29239..29484 + 246 WP_002311817.1 hypothetical protein -
JCP87_RS16055 29786..29881 - 96 WP_106913803.1 type I toxin-antitoxin system Fst family toxin -
JCP87_RS16060 30607..31287 - 681 WP_001015311.1 IS6-like element IS1216 family transposase -
JCP87_RS16065 31363..31929 + 567 Protein_38 hypothetical protein -
JCP87_RS16070 32310..32489 + 180 WP_001120991.1 hypothetical protein -
JCP87_RS16075 32620..32889 + 270 WP_000388479.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JCP87_RS16080 32882..33139 + 258 WP_000588503.1 Txe/YoeB family addiction module toxin Toxin
JCP87_RS16085 33777..34364 + 588 Protein_42 hypothetical protein -
JCP87_RS16090 34519..35838 + 1320 WP_000202380.1 IS1380-like element IS1678 family transposase -
JCP87_RS16095 36042..36284 + 243 Protein_44 hypothetical protein -
JCP87_RS16100 36449..37063 - 615 WP_001261742.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Non-Mobilizable plasmid erm(B) / ant(6)-Ia / aph(3')-III / VanHAX - 1..41600 41600
- inside IScluster/Tn erm(B) / ant(6)-Ia / aph(3')-III / VanHAX - 1657..35838 34181


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.53 Da        Isoelectric Point: 8.4369

>T184393 WP_000588503.1 NZ_CP066385:32882-33139 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

>T184393 NZ_CP087638:1654-1920 [Klebsiella pneumoniae subsp. pneumoniae]
TTGGTCTGGACGATTAACTATTCCGATCGGGCGCTCAAATCGTTACGCAAGATGGACAAACAGAACGCACGACGGATTGT
GGATTTTATGAGTTTACGCATTGCAGTTGCTGCCGATCCTCGCCAGTCAGGGAAGCCGCTCAAAGGTGAGCTGGGCGAGT
TCTGGCGCTATCGGGTGGGAGATTATCGCGTTCTGTGTGAGATCCGAGATGACGAGCTTGTTATCCTTGCCGCCACGATT
GGACATCGCCGCGAAGTTTACGACTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10373.51 Da        Isoelectric Point: 4.4346

>AT184393 WP_000388479.1 NZ_CP066385:32620-32889 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Download         Length: 270 bp

>AT184393 NZ_CP087638:1446-1670 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCTTGCTATCCGGTTATCTGATGAGATTGAGTCCCGTCTGGACTCGCTGGCGAAGCAAACCGGCAGAACAAAGACGTT
TTATGCGCGGGAAGCAATACTGGCGCATCTGGAAGACCTGGAGGATTATTATCTTTCAGCAGAAACTGCTGCACGCGTTC
GCCGTGGTGATGAAGCAGTGCATTCGTCTGAAGACGTGAGGAAGTCACTTGGTCTGGACGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZWU7

References