Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 19929..20442 Replicon plasmid pSE1
Accession NZ_CP066375
Organism Staphylococcus epidermidis strain PH1-28

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag ICN77_RS00535 Protein ID WP_145353820.1
Coordinates 19929..20195 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A8B5RQB4
Locus tag ICN77_RS00540 Protein ID WP_002452575.1
Coordinates 20188..20442 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ICN77_RS00490 14936..15097 - 162 WP_198895615.1 hypothetical protein -
ICN77_RS00495 15635..16309 - 675 WP_001105987.1 IS6-like element IS257 family transposase -
ICN77_RS00500 16456..16635 + 180 WP_198895616.1 CsbD family protein -
ICN77_RS00505 16668..17027 - 360 WP_103463604.1 YolD-like family protein -
ICN77_RS00510 17192..17449 + 258 WP_002441972.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
ICN77_RS00515 17449..17715 + 267 WP_145353822.1 Txe/YoeB family addiction module toxin -
ICN77_RS00520 17732..17902 + 171 WP_016898857.1 hypothetical protein -
ICN77_RS00525 18248..18520 + 273 WP_198895617.1 hypothetical protein -
ICN77_RS00530 18818..19366 + 549 WP_064657848.1 recombinase family protein -
ICN77_RS00535 19929..20195 - 267 WP_145353820.1 Txe/YoeB family addiction module toxin Toxin
ICN77_RS00540 20188..20442 - 255 WP_002452575.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ICN77_RS00545 20566..20739 + 174 WP_145353838.1 plasmid recombination protein -
ICN77_RS00550 21393..21721 - 329 Protein_27 replication protein -
ICN77_RS00555 22103..22273 + 171 WP_002456306.1 hypothetical protein -
ICN77_RS00560 22627..23277 + 651 Protein_29 CPBP family intramembrane metalloprotease -
ICN77_RS00565 23738..25006 - 1269 WP_198895618.1 penicillin-binding protein PBP4 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..51568 51568
- flank IS/Tn - - 15635..16309 674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10519.18 Da        Isoelectric Point: 10.1215

>T184376 WP_145353820.1 NZ_CP066375:c20195-19929 [Staphylococcus epidermidis]
MNKYNVTFTPTAFEDYKYWQTQDKKLLKKINSLIKNIQRNGILEGEGKPEPLKGNLKGYYSRRINHEHRLVYTIKDPSII
IIACRYHY

Download         Length: 267 bp

>T184376 NZ_CP087632:53486-53638 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGTACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9651.68 Da        Isoelectric Point: 4.1237

>AT184376 WP_002452575.1 NZ_CP066375:c20442-20188 [Staphylococcus epidermidis]
MTVLTYSNARKDFRKLIDKVNDDSDTVTITTNDRNAVLISEDDYNSIMETLYLQQSPVNAKRLAQSMEEAERVNTVEVDI
TTYE

Download         Length: 255 bp

>AT184376 NZ_CP087632:c53436-53374 [Klebsiella pneumoniae subsp. pneumoniae]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A8B5RQB4

References