Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 17192..17715 | Replicon | plasmid pSE1 |
| Accession | NZ_CP066375 | ||
| Organism | Staphylococcus epidermidis strain PH1-28 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | - |
| Locus tag | ICN77_RS00515 | Protein ID | WP_145353822.1 |
| Coordinates | 17449..17715 (+) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | C5QR06 |
| Locus tag | ICN77_RS00510 | Protein ID | WP_002441972.1 |
| Coordinates | 17192..17449 (+) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ICN77_RS00475 | 12592..13413 | - | 822 | Protein_12 | hypothetical protein | - |
| ICN77_RS00480 | 13425..13808 | - | 384 | WP_103463593.1 | hypothetical protein | - |
| ICN77_RS00485 | 13810..14088 | - | 279 | WP_103463592.1 | hypothetical protein | - |
| ICN77_RS00490 | 14936..15097 | - | 162 | WP_198895615.1 | hypothetical protein | - |
| ICN77_RS00495 | 15635..16309 | - | 675 | WP_001105987.1 | IS6-like element IS257 family transposase | - |
| ICN77_RS00500 | 16456..16635 | + | 180 | WP_198895616.1 | CsbD family protein | - |
| ICN77_RS00505 | 16668..17027 | - | 360 | WP_103463604.1 | YolD-like family protein | - |
| ICN77_RS00510 | 17192..17449 | + | 258 | WP_002441972.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| ICN77_RS00515 | 17449..17715 | + | 267 | WP_145353822.1 | Txe/YoeB family addiction module toxin | Toxin |
| ICN77_RS00520 | 17732..17902 | + | 171 | WP_016898857.1 | hypothetical protein | - |
| ICN77_RS00525 | 18248..18520 | + | 273 | WP_198895617.1 | hypothetical protein | - |
| ICN77_RS00530 | 18818..19366 | + | 549 | WP_064657848.1 | recombinase family protein | - |
| ICN77_RS00535 | 19929..20195 | - | 267 | WP_145353820.1 | Txe/YoeB family addiction module toxin | - |
| ICN77_RS00540 | 20188..20442 | - | 255 | WP_002452575.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| ICN77_RS00545 | 20566..20739 | + | 174 | WP_145353838.1 | plasmid recombination protein | - |
| ICN77_RS00550 | 21393..21721 | - | 329 | Protein_27 | replication protein | - |
| ICN77_RS00555 | 22103..22273 | + | 171 | WP_002456306.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..51568 | 51568 | |
| - | flank | IS/Tn | - | - | 15635..16309 | 674 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10691.35 Da Isoelectric Point: 10.3481
>T184375 WP_145353822.1 NZ_CP066375:17449-17715 [Staphylococcus epidermidis]
MAKYKINIKNSAKTDLKKIKRSHLQEQFLKIVEILKYNPYQQSQSFEKLHPKHLGRYSRRINHQHRVVYTIDEENKEVLI
LAAWSHYE
MAKYKINIKNSAKTDLKKIKRSHLQEQFLKIVEILKYNPYQQSQSFEKLHPKHLGRYSRRINHQHRVVYTIDEENKEVLI
LAAWSHYE
Download Length: 267 bp
>T184375 NZ_CP087631:c102929-102486 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAACAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
TGGGCACGCTATCGCGGCCGGCGCCGTCCTAGTGACGAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGAAAGCCGCTCTCTGCAGGGTAATTTCTTGA
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAACAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
TGGGCACGCTATCGCGGCCGGCGCCGTCCTAGTGACGAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGAAAGCCGCTCTCTGCAGGGTAATTTCTTGA
Antitoxin
Download Length: 86 a.a. Molecular weight: 10041.10 Da Isoelectric Point: 4.5610
>AT184375 WP_002441972.1 NZ_CP066375:17192-17449 [Staphylococcus epidermidis]
MKSKTPTEARKDFYQLLKRVNNDHEPVYIEGKYDESNAVIIGMEDWRSINETIYLEATGTMDKVREREHDNSGYTNIDDI
DWARL
MKSKTPTEARKDFYQLLKRVNNDHEPVYIEGKYDESNAVIIGMEDWRSINETIYLEATGTMDKVREREHDNSGYTNIDDI
DWARL
Download Length: 258 bp
>AT184375 NZ_CP087631:c103156-102926 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGCTCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGCTCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|