Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 165072..165711 Replicon plasmid pAK76
Accession NZ_CP066360
Organism Sinorhizobium meliloti strain AK76

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JFX10_RS25530 Protein ID WP_198868956.1
Coordinates 165391..165711 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JFX10_RS25525 Protein ID WP_198868883.1
Coordinates 165072..165398 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JFX10_RS25505 161679..161867 - 189 WP_198868880.1 hypothetical protein -
JFX10_RS25510 162127..162843 - 717 WP_198868881.1 SMC-Scp complex subunit ScpB -
JFX10_RS25515 162840..163740 - 901 Protein_153 DUF1403 family protein -
JFX10_RS25520 163915..165048 + 1134 WP_198868882.1 site-specific integrase -
JFX10_RS25525 165072..165398 - 327 WP_198868883.1 helix-turn-helix domain-containing protein Antitoxin
JFX10_RS25530 165391..165711 - 321 WP_198868956.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JFX10_RS25535 165912..166388 + 477 Protein_157 recombinase family protein -
JFX10_RS25540 166333..166569 - 237 WP_198868884.1 IS66 family insertion sequence element accessory protein TnpB -
JFX10_RS25545 166566..166952 - 387 WP_015008426.1 transposase -
JFX10_RS25550 167523..168800 + 1278 WP_198868885.1 replication protein C -
JFX10_RS25555 168797..169308 + 512 Protein_161 thermonuclease family protein -
JFX10_RS25560 169705..170037 + 333 WP_198868886.1 DUF736 family protein -
JFX10_RS25565 170158..170361 + 204 WP_198868887.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..172809 172809


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(2-94)

Antitoxin

HigA2-like, helix-turn-helix domain

(11-85)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12133.24 Da        Isoelectric Point: 10.3145

>T184327 WP_198868956.1 NZ_CP066360:c165711-165391 [Sinorhizobium meliloti]
ITDLPADVRVELLAHLVLLREKGLRLGRPEVDTLEGSRHANMKELRVKVLKVQWRFAFAFDPERKAVVLCGAAKSGVSQK
LFYKRLIDLADKRYAEHLSELEKKHG

Download         Length: 321 bp

>T184327 NZ_CP087614:42189-42500 [Klebsiella pneumoniae subsp. pneumoniae]
GTGCATGTTATATCACGAGCCCCTTTTGATGAGGCGGCGAGACACTATCCGAATGATGCTGCGGCCATCGATGACACCTA
TCGAGTACTAAAGCGTGTTGTCGCAAAAAAACCGGATGAGCTAAAGCGATACTTTACTAGTCTGGATCGCATGAAATACC
GGGAAAAATGGTGGGTTATCGATATCGGCGGTAATAACCTTAGAATGATGTTTTTTGCTGATTTTGAGCGCGGAAAGATA
TTCGTCAAACACATAACCACCCATGCTGAATATGATCGCTTAACGAAATATTATCGGGAGCACAAAGAATGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 11861.47 Da        Isoelectric Point: 8.6037

>AT184327 WP_198868883.1 NZ_CP066360:c165398-165072 [Sinorhizobium meliloti]
MDDLDKLIKTLPEDEQRAIAARTEELVTAHNLRELRALAGRTQEDVSAATGFKQTNVSRLEKRADMKLSTLRDYVESLGG
TLKIVADVAGKKVDLSSIAERSRHGAKA

Download         Length: 327 bp

>AT184327 NZ_CP087614:42497-42913 [Klebsiella pneumoniae subsp. pneumoniae]
ATGATTTTTAGCGATGCCATTAAAGCGGCGAATGACCTGGCGAGTATTGTCCCTCTGCTGGGTGGCAGTTCGTCCCGCAA
AGATTACGAAGAGGCACTTAAACTCGTTGAATATCTTCTGGAACATGAGCCGGACAGCCCGCTGGTTGATATGCTGACTG
CCCGCATTGATGCCTGGGAAGATACCGCGGTGGAATTTGAAGAATTTAATACGCGTATCGAAGCTGGTAAAAACGGTGTA
TCGTTGCTACGGGTTCTCATGCAGCAACGCGGGCTTTCACAGTCCGATTTTGAAAACGAGATAGGCAAAAAATCGCTCGT
CAGCCGGATCCTCAGTGGTGAACGCAGTTTGACCCTTGATCACATGCGTGCGCTGGCAAATCGATTTCAAATCCCGGTCT
CGATGTTTGTTGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References