Detailed information of TA system TA184194

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 47798..48456
• Replicon: plasmid pG20AB007-1
• Accession: NZ_CP066238
• Organism: Acinetobacter baumannii strain G20AB007

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: JCR16_RS19545
• Protein ID: WP_000312250.1
• Coordinates: 48097..48456 (-)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: JCR16_RS19540
• Protein ID: WP_001096429.1
• Coordinates: 47798..48097 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JCR16_RS19495	42831..43088	+	258	WP_000834292.1	hypothetical protein	-
JCR16_RS19500	43093..43665	+	573	WP_000429351.1	hypothetical protein	-
JCR16_RS19505	43641..43820	+	180	WP_002081921.1	hypothetical protein	-
JCR16_RS19510	43837..44466	+	630	WP_002081923.1	hypothetical protein	-
JCR16_RS19515	44506..45015	+	510	WP_001043199.1	hypothetical protein	-
JCR16_RS19520	45096..45650	+	555	WP_000790085.1	hypothetical protein	-
JCR16_RS19525	45700..46236	+	537	WP_000731981.1	hypothetical protein	-
JCR16_RS19530	46859..47341	+	483	WP_001052677.1	hypothetical protein	-
JCR16_RS19535	47434..47697	-	264	WP_000110863.1	hypothetical protein	-
JCR16_RS19540	47798..48097	-	300	WP_001096429.1	helix-turn-helix transcriptional regulator	Antitoxin
JCR16_RS19545	48097..48456	-	360	WP_000312250.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JCR16_RS19550	48657..49223	+	567	WP_041171756.1	hypothetical protein	-
JCR16_RS19555	49272..49454	+	183	WP_000373385.1	hypothetical protein	-
JCR16_RS19560	49521..50219	+	699	WP_000873190.1	hypothetical protein	-
JCR16_RS19565	50358..50741	+	384	WP_000654349.1	hypothetical protein	-
JCR16_RS19570	50808..51566	+	759	WP_001053129.1	hypothetical protein	-
JCR16_RS19575	52636..52950	+	315	WP_000708714.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..73361	73361

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (14-109)

Antitoxin

• HigA2-like, helix-turn-helix domain (12-88)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 13751.62 Da
• Isoelectric Point: 4.8212

>T184194 WP_000312250.1 NZ_CP066238:c48456-48097 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Nucleotide

• Length: 360 bp

>T184194 NZ_CP087564:c2971319-2971212 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11012.93 Da
• Isoelectric Point: 10.4856

>AT184194 WP_001096429.1 NZ_CP066238:c48097-47798 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Nucleotide

• Length: 300 bp

>AT184194 NZ_CP087564:2971367-2971433 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT