Detailed information of TA system TA184191

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 25663..26321
• Replicon: plasmid pG20AB009-1
• Accession: NZ_CP066236
• Organism: Acinetobacter baumannii strain G20AB009

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: JCR17_RS19455
• Protein ID: WP_000312250.1
• Coordinates: 25663..26022 (+)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: JCR17_RS19460
• Protein ID: WP_001096429.1
• Coordinates: 26022..26321 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JCR17_RS19425	21169..21483	-	315	WP_000708714.1	hypothetical protein	-
JCR17_RS19430	22553..23311	-	759	WP_001053129.1	hypothetical protein	-
JCR17_RS19435	23378..23761	-	384	WP_000654349.1	hypothetical protein	-
JCR17_RS19440	23900..24598	-	699	WP_000873190.1	hypothetical protein	-
JCR17_RS19445	24665..24847	-	183	WP_000373385.1	hypothetical protein	-
JCR17_RS19450	24896..25462	-	567	WP_041171756.1	hypothetical protein	-
JCR17_RS19455	25663..26022	+	360	WP_000312250.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JCR17_RS19460	26022..26321	+	300	WP_001096429.1	helix-turn-helix transcriptional regulator	Antitoxin
JCR17_RS19465	26422..26685	+	264	WP_000110863.1	hypothetical protein	-
JCR17_RS19470	26778..27260	-	483	WP_001052677.1	hypothetical protein	-
JCR17_RS19475	27883..28419	-	537	WP_000731981.1	hypothetical protein	-
JCR17_RS19480	28469..29023	-	555	WP_000790085.1	hypothetical protein	-
JCR17_RS19485	29104..29613	-	510	WP_001043199.1	hypothetical protein	-
JCR17_RS19490	29653..30282	-	630	WP_002081923.1	hypothetical protein	-
JCR17_RS19495	30299..30478	-	180	WP_002081921.1	hypothetical protein	-
JCR17_RS19500	30454..31026	-	573	WP_000429351.1	hypothetical protein	-
JCR17_RS19505	31031..31288	-	258	WP_000834292.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..73361	73361

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (14-109)

Antitoxin

• HigA2-like, helix-turn-helix domain (12-88)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 13751.62 Da
• Isoelectric Point: 4.8212

>T184191 WP_000312250.1 NZ_CP066236:25663-26022 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Nucleotide

• Length: 360 bp

>T184191 NZ_CP087564:c2441975-2441679 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11012.93 Da
• Isoelectric Point: 10.4856

>AT184191 WP_001096429.1 NZ_CP066236:26022-26321 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Nucleotide

• Length: 300 bp

>AT184191 NZ_CP087564:c2441677-2441282 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCAAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA