Detailed information of TA system TA184184

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 19505..20163
• Replicon: plasmid pG20AB011-1
• Accession: NZ_CP066230
• Organism: Acinetobacter baumannii strain G20AB011

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: JCR19_RS19385
• Protein ID: WP_000312250.1
• Coordinates: 19804..20163 (-)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: JCR19_RS19380
• Protein ID: WP_001096429.1
• Coordinates: 19505..19804 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JCR19_RS19335	14560..14817	+	258	WP_000834292.1	hypothetical protein	-
JCR19_RS19340	14822..15394	+	573	WP_000429351.1	hypothetical protein	-
JCR19_RS19345	15370..15549	+	180	WP_002081921.1	hypothetical protein	-
JCR19_RS19350	15566..16195	+	630	WP_002081923.1	hypothetical protein	-
JCR19_RS19355	16235..16744	+	510	WP_001043199.1	hypothetical protein	-
JCR19_RS19360	16825..17379	+	555	WP_000790085.1	hypothetical protein	-
JCR19_RS19365	17429..17943	+	515	Protein_25	hypothetical protein	-
JCR19_RS19370	18566..19048	+	483	WP_001052677.1	hypothetical protein	-
JCR19_RS19375	19141..19404	-	264	WP_000110863.1	hypothetical protein	-
JCR19_RS19380	19505..19804	-	300	WP_001096429.1	helix-turn-helix transcriptional regulator	Antitoxin
JCR19_RS19385	19804..20163	-	360	WP_000312250.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JCR19_RS19390	20364..20930	+	567	WP_041171756.1	hypothetical protein	-
JCR19_RS19395	20979..21161	+	183	WP_000373385.1	hypothetical protein	-
JCR19_RS19400	21228..21926	+	699	WP_000873190.1	hypothetical protein	-
JCR19_RS19405	22065..22448	+	384	WP_000654349.1	hypothetical protein	-
JCR19_RS19410	22515..23273	+	759	WP_001053129.1	hypothetical protein	-
JCR19_RS19415	24343..24657	+	315	WP_000708714.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..73339	73339

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (14-109)

Antitoxin

• HigA2-like, helix-turn-helix domain (12-88)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 13751.62 Da
• Isoelectric Point: 4.8212

>T184184 WP_000312250.1 NZ_CP066230:c20163-19804 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Nucleotide

• Length: 360 bp

>T184184 NZ_CP087564:c1069518-1069415 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTTTTTTT

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11012.93 Da
• Isoelectric Point: 10.4856

>AT184184 WP_001096429.1 NZ_CP066230:c19804-19505 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Nucleotide

• Length: 300 bp

>AT184184 NZ_CP087564:1069414-1069648 [Escherichia coli]
TAAAAAAAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCA
TTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAAT
AAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCGTTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT