Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 19505..20163 Replicon plasmid pG20AB011-1
Accession NZ_CP066230
Organism Acinetobacter baumannii strain G20AB011

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JCR19_RS19385 Protein ID WP_000312250.1
Coordinates 19804..20163 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JCR19_RS19380 Protein ID WP_001096429.1
Coordinates 19505..19804 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JCR19_RS19335 14560..14817 + 258 WP_000834292.1 hypothetical protein -
JCR19_RS19340 14822..15394 + 573 WP_000429351.1 hypothetical protein -
JCR19_RS19345 15370..15549 + 180 WP_002081921.1 hypothetical protein -
JCR19_RS19350 15566..16195 + 630 WP_002081923.1 hypothetical protein -
JCR19_RS19355 16235..16744 + 510 WP_001043199.1 hypothetical protein -
JCR19_RS19360 16825..17379 + 555 WP_000790085.1 hypothetical protein -
JCR19_RS19365 17429..17943 + 515 Protein_25 hypothetical protein -
JCR19_RS19370 18566..19048 + 483 WP_001052677.1 hypothetical protein -
JCR19_RS19375 19141..19404 - 264 WP_000110863.1 hypothetical protein -
JCR19_RS19380 19505..19804 - 300 WP_001096429.1 helix-turn-helix transcriptional regulator Antitoxin
JCR19_RS19385 19804..20163 - 360 WP_000312250.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JCR19_RS19390 20364..20930 + 567 WP_041171756.1 hypothetical protein -
JCR19_RS19395 20979..21161 + 183 WP_000373385.1 hypothetical protein -
JCR19_RS19400 21228..21926 + 699 WP_000873190.1 hypothetical protein -
JCR19_RS19405 22065..22448 + 384 WP_000654349.1 hypothetical protein -
JCR19_RS19410 22515..23273 + 759 WP_001053129.1 hypothetical protein -
JCR19_RS19415 24343..24657 + 315 WP_000708714.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..73339 73339


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-109)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-88)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13751.62 Da        Isoelectric Point: 4.8212

>T184184 WP_000312250.1 NZ_CP066230:c20163-19804 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Download         Length: 360 bp

>T184184 NZ_CP087564:c1069518-1069415 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTTTTTTT

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11012.93 Da        Isoelectric Point: 10.4856

>AT184184 WP_001096429.1 NZ_CP066230:c19804-19505 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Download         Length: 300 bp

>AT184184 NZ_CP087564:1069414-1069648 [Escherichia coli]
TAAAAAAAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCA
TTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAAT
AAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCGTTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References