Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1964124..1964641 Replicon chromosome
Accession NZ_CP066224
Organism Jeotgalicoccus sp. ATCC 8456

Toxin (Protein)


Gene name yoeB Uniprot ID A0A7T4X1B6
Locus tag JEM45_RS10210 Protein ID WP_026866763.1
Coordinates 1964372..1964641 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A7T5BTL4
Locus tag JEM45_RS10205 Protein ID WP_026866762.1
Coordinates 1964124..1964372 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JEM45_RS10180 1959373..1960188 + 816 WP_035856234.1 PHP domain-containing protein -
JEM45_RS10185 1960286..1961353 + 1068 WP_035856236.1 PhnD/SsuA/transferrin family substrate-binding protein -
JEM45_RS10190 1961573..1962340 + 768 WP_026866759.1 phosphonate ABC transporter ATP-binding protein -
JEM45_RS10195 1962351..1963163 + 813 WP_084145743.1 ABC transporter permease subunit -
JEM45_RS10200 1963163..1963984 + 822 WP_026866761.1 ABC transporter permease subunit -
JEM45_RS10205 1964124..1964372 + 249 WP_026866762.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
JEM45_RS10210 1964372..1964641 + 270 WP_026866763.1 Txe/YoeB family addiction module toxin Toxin
JEM45_RS10215 1965075..1965893 + 819 WP_166627074.1 alpha/beta hydrolase -
JEM45_RS10220 1965914..1966501 + 588 WP_166627073.1 nitroreductase -
JEM45_RS10225 1966502..1966666 + 165 WP_156889150.1 hypothetical protein -
JEM45_RS10230 1967250..1968047 + 798 WP_198687990.1 polysaccharide deacetylase family protein -
JEM45_RS10235 1968263..1969360 + 1098 WP_156889155.1 putative glycoside hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10640.19 Da        Isoelectric Point: 9.8632

>T184181 WP_026866763.1 NZ_CP066224:1964372-1964641 [Jeotgalicoccus sp. ATCC 8456]
MTKLNITFSPQAFEDYEYFQVKDRRLVKRINQLLKSISRDGFLEGIGKPEKLVGNYSGYYSRRINHEHRLVYTVNEYAIL
VASCRYHYK

Download         Length: 270 bp

>T184181 NZ_CP087564:606132-606308 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9526.68 Da        Isoelectric Point: 4.6017

>AT184181 WP_026866762.1 NZ_CP066224:1964124-1964372 [Jeotgalicoccus sp. ATCC 8456]
MTVKSYSYVRENFKDMINKVNDDSDAIIITTKDRNAVMMSEESYNEIMETLYLQQSPSNAKRLSESIENLERGNVRNKDI
SI

Download         Length: 249 bp

>AT184181 NZ_CP087564:606354-606770 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T4X1B6

Antitoxin

Source ID Structure
AlphaFold DB A0A7T5BTL4

References