Detailed information of TA system TA184113

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 34900..35169
• Replicon: plasmid unnamed2
• Accession: NZ_CP066153
• Organism: Klebsiella pneumoniae strain KP697

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: JDZ44_RS28485
• Protein ID: WP_001372321.1
• Coordinates: 35044..35169 (+)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	34900..34965 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JDZ44_RS28455	30610..31137	+	528	WP_000290834.1	single-stranded DNA-binding protein	-
JDZ44_RS28460	31195..31428	+	234	WP_000006003.1	DUF905 family protein	-
JDZ44_RS28465	31489..33512	+	2024	Protein_43	ParB/RepB/Spo0J family partition protein	-
JDZ44_RS28470	33581..34015	+	435	WP_000845953.1	conjugation system SOS inhibitor PsiB	-
JDZ44_RS28475	34012..34731	+	720	WP_001276217.1	plasmid SOS inhibition protein A	-
-	34743..34967	+	225	NuclAT_0	-	-
-	34743..34967	+	225	NuclAT_0	-	-
-	34743..34967	+	225	NuclAT_0	-	-
-	34743..34967	+	225	NuclAT_0	-	-
-	34900..34965	-	66	-	-	Antitoxin
JDZ44_RS28480	34953..35102	+	150	Protein_46	plasmid maintenance protein Mok	-
JDZ44_RS28485	35044..35169	+	126	WP_001372321.1	type I toxin-antitoxin system Hok family toxin	Toxin
JDZ44_RS28490	35488..35784	-	297	Protein_48	hypothetical protein	-
JDZ44_RS28495	36084..36380	+	297	WP_001272251.1	hypothetical protein	-
JDZ44_RS28500	36491..37312	+	822	WP_001234445.1	DUF932 domain-containing protein	-
JDZ44_RS28505	37609..38256	-	648	WP_015059008.1	transglycosylase SLT domain-containing protein	-
JDZ44_RS28510	38533..38916	+	384	WP_000124981.1	conjugal transfer relaxosome DNA-binding protein TraM	-
JDZ44_RS28515	39197..39901	+	705	WP_001067855.1	IS6-like element IS26 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	blaCTX-M-65 / blaTEM-1B / rmtB / blaSHV-12 / blaKPC-2	-	1..133625	133625

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4780.69 Da
• Isoelectric Point: 8.5110

>T184113 WP_001372321.1 NZ_CP066153:35044-35169 [Klebsiella pneumoniae]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 126 bp

>T184113 NZ_CP087377:262820-262927 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 66 bp

>AT184113 NZ_CP066153:c34965-34900 [Klebsiella pneumoniae]
GTGGACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCT

Structures

Antitoxin