184084

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 39977..40623 Replicon plasmid unnamed1
Accession NZ_CP066145
Organism Escherichia coli strain ZLWT

Toxin (Protein)


Gene name higB Uniprot ID A0A7R6ZH56
Locus tag ICI43_RS24760 Protein ID WP_000269913.1
Coordinates 39977..40324 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1V3UZT0
Locus tag ICI43_RS24765 Protein ID WP_001259436.1
Coordinates 40324..40623 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ICI43_RS24730 35177..35704 - 528 WP_000972103.1 tail fiber assembly protein -
ICI43_RS24735 35706..36632 - 927 Protein_48 phage tail protein -
ICI43_RS24740 36798..37352 + 555 WP_001199265.1 recombinase family protein -
ICI43_RS24745 37678..38514 + 837 WP_001139598.1 hypothetical protein -
ICI43_RS24750 39158..39445 + 288 WP_000356589.1 hypothetical protein -
ICI43_RS24755 39469..39732 + 264 WP_000424604.1 hypothetical protein -
ICI43_RS24760 39977..40324 + 348 WP_000269913.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ICI43_RS24765 40324..40623 + 300 WP_001259436.1 XRE family transcriptional regulator Antitoxin
ICI43_RS24770 40787..41167 + 381 WP_000061764.1 hypothetical protein -
ICI43_RS24775 41231..41503 + 273 WP_000148349.1 helix-turn-helix domain-containing protein -
ICI43_RS24780 42114..42302 + 189 WP_000986262.1 hypothetical protein -
ICI43_RS24785 42313..43455 - 1143 WP_000854799.1 ORF6N domain-containing protein -
ICI43_RS24790 43452..43643 - 192 WP_000183352.1 hypothetical protein -
ICI43_RS24795 44217..44789 + 573 WP_000137931.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..48488 48488


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13486.53 Da        Isoelectric Point: 9.8723

>T184084 WP_000269913.1 NZ_CP066145:39977-40324 [Escherichia coli]
MWTVLFSQRFDGWLNEQEDALQEKVLADLKKLQVYGPELPRPYADTVKGSRYKNMKELRVQFSGRPIRAFYAFDPIRRAI
VLCAGDKSNDKRFYKKLVRIAEDEFAAHLNTLESK

Download         Length: 348 bp

>T184084 NZ_CP087329:37323-37613 [Acinetobacter baumannii]
ATGGTTAAAGTCGCTGATTTACCAAGTTTTGATATGGCTGAGTCACTCAAAACTGAAGAAGATATTGTAATGTACCTCAA
TATGGTTCTTGAAGAAAATGATCCTGCTGAATTAGCGCACGCACTTGGTGTAATTGCTAAAGCAAGAGGTATGACCCAAA
TTGCGAAAGAAGCAGGTATTGGACGAGAAGCCCTTTACAAAGCACTTCGTCAAGACTCAACGCCTCGTTTTGATACGATC
AACCGTGTTGTGAATGCTTTAGGTTTAAAATTGACAGTTCAACATACTTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11074.92 Da        Isoelectric Point: 5.2090

>AT184084 WP_001259436.1 NZ_CP066145:40324-40623 [Escherichia coli]
MRTLDEVIASRSPESQARIKEMADEMILEVGLQMMREELQLSQKQVAEAMGISQPAVTKLEQRGNDLKLATLKRYVEAMG
GKLSLDVELPTGKRIAFNI

Download         Length: 300 bp

>AT184084 NZ_CP087329:37025-37321 [Acinetobacter baumannii]
ATGATTGAAATTAAACGTCTGCCTGAATTTGATGAATGGCTAGATGGTCTTAAAGACAATATGACTCGAATCCGCTTGAA
TCGTCGATTAGATAAGGTCCAACGTGGTAATTGGGGTGACATTAAACCACTCCAAGATGGTGTCTGGGAAATGAGAGAGT
TCTTTGGTGCTGGTTGGCGGATGTACTACATCCAACATGGTGACGTTGTGATCGTGATGCTTGGTGGTGGTGAAAAATCT
ACACAGAAAGATGACATCAAGAAAGCGGTCAAACTATCGAAAACATTGGAGGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7R6ZH56

Antitoxin

Source ID Structure
AlphaFold DB A0A1V3UZT0

References