Detailed information of TA system TA184077

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4269360..4269618
• Replicon: chromosome
• Accession: NZ_CP066144
• Organism: Escherichia coli strain ZLWT

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: ICI43_RS20430
• Protein ID: WP_000809168.1
• Coordinates: 4269466..4269618 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	4269360..4269417 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ICI43_RS20415	4265189..4266448	-	1260	WP_000494928.1	hypothetical protein	-
ICI43_RS20420	4266577..4268070	-	1494	WP_001443162.1	sulfatase-like hydrolase/transferase	-
ICI43_RS20425	4268090..4268851	-	762	WP_001274832.1	hypothetical protein	-
-	4269360..4269417	-	58	-	-	Antitoxin
ICI43_RS20430	4269466..4269618	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
ICI43_RS20435	4269723..4270853	-	1131	WP_001118465.1	molecular chaperone DnaJ	-
ICI43_RS20440	4270942..4272858	-	1917	WP_000516135.1	molecular chaperone DnaK	-
ICI43_RS20445	4273230..4273634	+	405	WP_000843687.1	DUF2541 family protein	-
ICI43_RS20450	4273660..4274373	+	714	WP_001102391.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T184077 WP_000809168.1 NZ_CP066144:4269466-4269618 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T184077 NZ_CP087326:88161-88457 [Acinetobacter baumannii]
ATGATTGAAATTAAACGTCTGCCTGAATTTGATGAATGGCTAGATGGTCTTAAAGACAATATGACTCGAATCCGCTTGAA
TCGTCGATTAGATAAGGTCCAACGTGGTAATTGGGGTGACATTAAACCACTCCAAGATGGTGTCTGGGAAATGAGAGAGT
TCTTTGGTGCTGGTTGGCGGATGTACTACATCCAACATGGTGACGTTGTGATCGTGATGCTTGGTGGTGGTGAAAAATCT
ACACAGAAAGATGACATCAAGAAAGCGGTCAAACTATCGAAAACATTGGAGGATTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT184077 NZ_CP066144:c4269417-4269360 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin