Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4033071..4033869 Replicon chromosome
Accession NZ_CP066144
Organism Escherichia coli strain ZLWT

Toxin (Protein)


Gene name yeeV Uniprot ID Q8VRA6
Locus tag ICI43_RS19330 Protein ID WP_000854730.1
Coordinates 4033492..4033869 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P0SQV8
Locus tag ICI43_RS19325 Protein ID WP_001285481.1
Coordinates 4033071..4033445 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ICI43_RS19285 4029046..4029498 + 453 WP_000682723.1 hypothetical protein -
ICI43_RS19290 4029616..4029849 + 234 WP_001213776.1 DUF905 family protein -
ICI43_RS19295 4029949..4030770 + 822 WP_001234359.1 DUF945 domain-containing protein -
ICI43_RS19300 4030770..4031015 + 246 WP_001164966.1 hypothetical protein -
ICI43_RS19305 4031109..4031582 + 474 WP_001313575.1 antirestriction protein -
ICI43_RS19310 4031598..4032074 + 477 WP_001313574.1 RadC family protein -
ICI43_RS19315 4032137..4032358 + 222 WP_000692315.1 DUF987 domain-containing protein -
ICI43_RS19320 4032377..4033021 + 645 WP_000086761.1 hypothetical protein -
ICI43_RS19325 4033071..4033445 + 375 WP_001285481.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
ICI43_RS19330 4033492..4033869 + 378 WP_000854730.1 TA system toxin CbtA family protein Toxin
ICI43_RS19335 4033866..4034358 + 493 Protein_3793 hypothetical protein -
ICI43_RS19340 4034437..4035425 - 989 Protein_3794 IS630 family transposase -
ICI43_RS19345 4035573..4035761 - 189 Protein_3795 IS66 family transposase -
ICI43_RS19350 4035822..4036955 + 1134 WP_000555401.1 IS110-like element ISEc45 family transposase -
ICI43_RS19355 4037209..4038613 - 1405 Protein_3797 IS66 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4033071..4043558 10487


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14212.21 Da        Isoelectric Point: 7.2923

>T184075 WP_000854730.1 NZ_CP066144:4033492-4033869 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRSNYRMVNDIIRGEHSEAKR

Download         Length: 378 bp

>T184075 NZ_CP087325:3002253-3002432 [Acinetobacter baumannii]
ATGAGCTTCAACGAGTTTAAACGATGGCTAATTGCACAGGGAGTTATCTTTGTGCGTAAAGGTAAGGGATCACATATGAT
TATTGAATTTAACGGTAAGAAGACTGTTTTCCCTAACCACGGGAAAAAAGAAATTCCTGAAGGCACTCGTTTAAAGATCA
AAAAGGATTTGGGGCTTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13817.53 Da        Isoelectric Point: 4.7511

>AT184075 WP_001285481.1 NZ_CP066144:4033071-4033445 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTIG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT184075 NZ_CP087325:3002518-3002931 [Acinetobacter baumannii]
ATGAAATGTTATGTCAGTATTCATAGGGAGGGAGAGGCTTTTATAGTCAGCTCAAGTGAACTCCCTGAACTAAATAGTGT
AGGCTATACTTTAGAAGAAGCTTTATCAGAAGCTTTGGATGGTATAGAAACAGTATTCGAAATTTATATGGATGAGCGTA
AAGCCATCCCATTACCATCAAAAGGTAAGAAAGGTGAATATGCAGTTCATCTTCCAGTTCGAGTCGCTGCTAAGGTACGT
TTATATAATGAGATGATCTCACAAAACGTTACTAAAGCTGAATTAGCTCGTCGCTTGGGGTGGTTACAGAAGCAAGCCGA
TCGTTTGCTTTCATTAAAGCATTCAACAAAACTAGAATCGATTGAAAGTGCCTTCCAAGCATTAGGCAAGGATCTCGATA
TAGTTATCGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2V671

Antitoxin

Source ID Structure
AlphaFold DB A0A0P0SQV8

References