Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2135712..2136360 Replicon chromosome
Accession NZ_CP066142
Organism Morganella morganii strain FAM24206

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JC862_RS09885 Protein ID WP_107679151.1
Coordinates 2135712..2136056 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JC862_RS09890 Protein ID WP_107679152.1
Coordinates 2136061..2136360 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JC862_RS09875 (JC862_09880) 2131312..2132409 + 1098 WP_107679149.1 efflux RND transporter periplasmic adaptor subunit -
JC862_RS09880 (JC862_09885) 2132406..2135495 + 3090 WP_107679150.1 efflux RND transporter permease subunit -
JC862_RS09885 (JC862_09890) 2135712..2136056 + 345 WP_107679151.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JC862_RS09890 (JC862_09895) 2136061..2136360 + 300 WP_107679152.1 helix-turn-helix transcriptional regulator Antitoxin
JC862_RS09895 (JC862_09900) 2136414..2137286 - 873 WP_107679153.1 dimethyl sulfoxide reductase anchor subunit -
JC862_RS09900 (JC862_09905) 2137283..2137912 - 630 WP_107679154.1 dimethylsulfoxide reductase subunit B -
JC862_RS09905 (JC862_09910) 2137909..2140293 - 2385 WP_107679155.1 molybdopterin-dependent oxidoreductase -
JC862_RS09910 (JC862_09915) 2140659..2141147 - 489 WP_107679156.1 RidA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-83)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13331.30 Da        Isoelectric Point: 8.8135

>T184036 WP_107679151.1 NZ_CP066142:2135712-2136056 [Morganella morganii]
VWTVLLTDYFNEWLSKQDTRMKEKVLASLGNLEIYGPVLTRPYVDTVKTSQYPNMKELRIWHAGRAIRAFFAFDPERQAI
ILCAGDKGKDKRFYQTMIRIADEQFSSYLSATQE

Download         Length: 345 bp

>T184036 NZ_CP087294:4033648-4034112 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGCGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11166.90 Da        Isoelectric Point: 7.0156

>AT184036 WP_107679152.1 NZ_CP066142:2136061-2136360 [Morganella morganii]
MKTLQEVIAAQSPESRERIKQLTDELVLETGLQLLREELHISQKTLANNLGISQPAVTQIEQRGNDIKLATLKRYIEAMG
GTLRLTIELPTGDNRIFRV

Download         Length: 300 bp

>AT184036 NZ_CP087294:4033313-4033648 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCTGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References