Detailed information of TA system TA184036

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 2135712..2136360
• Replicon: chromosome
• Accession: NZ_CP066142
• Organism: Morganella morganii strain FAM24206

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: JC862_RS09885
• Protein ID: WP_107679151.1
• Coordinates: 2135712..2136056 (+)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: JC862_RS09890
• Protein ID: WP_107679152.1
• Coordinates: 2136061..2136360 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JC862_RS09875 (JC862_09880)	2131312..2132409	+	1098	WP_107679149.1	efflux RND transporter periplasmic adaptor subunit	-
JC862_RS09880 (JC862_09885)	2132406..2135495	+	3090	WP_107679150.1	efflux RND transporter permease subunit	-
JC862_RS09885 (JC862_09890)	2135712..2136056	+	345	WP_107679151.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JC862_RS09890 (JC862_09895)	2136061..2136360	+	300	WP_107679152.1	helix-turn-helix transcriptional regulator	Antitoxin
JC862_RS09895 (JC862_09900)	2136414..2137286	-	873	WP_107679153.1	dimethyl sulfoxide reductase anchor subunit	-
JC862_RS09900 (JC862_09905)	2137283..2137912	-	630	WP_107679154.1	dimethylsulfoxide reductase subunit B	-
JC862_RS09905 (JC862_09910)	2137909..2140293	-	2385	WP_107679155.1	molybdopterin-dependent oxidoreductase	-
JC862_RS09910 (JC862_09915)	2140659..2141147	-	489	WP_107679156.1	RidA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (32-83)

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 13331.30 Da
• Isoelectric Point: 8.8135

>T184036 WP_107679151.1 NZ_CP066142:2135712-2136056 [Morganella morganii]
VWTVLLTDYFNEWLSKQDTRMKEKVLASLGNLEIYGPVLTRPYVDTVKTSQYPNMKELRIWHAGRAIRAFFAFDPERQAI
ILCAGDKGKDKRFYQTMIRIADEQFSSYLSATQE

Nucleotide

• Length: 345 bp

>T184036 NZ_CP087294:4033648-4034112 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGCGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11166.90 Da
• Isoelectric Point: 7.0156

>AT184036 WP_107679152.1 NZ_CP066142:2136061-2136360 [Morganella morganii]
MKTLQEVIAAQSPESRERIKQLTDELVLETGLQLLREELHISQKTLANNLGISQPAVTQIEQRGNDIKLATLKRYIEAMG
GTLRLTIELPTGDNRIFRV

Nucleotide

• Length: 300 bp

>AT184036 NZ_CP087294:4033313-4033648 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCTGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA