Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2153289..2153937 Replicon chromosome
Accession NZ_CP066140
Organism Morganella morganii strain FAM24670

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JC861_RS09990 Protein ID WP_107679151.1
Coordinates 2153289..2153633 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JC861_RS09995 Protein ID WP_107679152.1
Coordinates 2153638..2153937 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JC861_RS09980 (JC861_09975) 2148889..2149986 + 1098 WP_107679149.1 efflux RND transporter periplasmic adaptor subunit -
JC861_RS09985 (JC861_09980) 2149983..2153072 + 3090 WP_107679150.1 efflux RND transporter permease subunit -
JC861_RS09990 (JC861_09985) 2153289..2153633 + 345 WP_107679151.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JC861_RS09995 (JC861_09990) 2153638..2153937 + 300 WP_107679152.1 helix-turn-helix transcriptional regulator Antitoxin
JC861_RS10000 (JC861_09995) 2153991..2154863 - 873 WP_107679153.1 dimethyl sulfoxide reductase anchor subunit -
JC861_RS10005 (JC861_10000) 2154860..2155489 - 630 WP_107679154.1 dimethylsulfoxide reductase subunit B -
JC861_RS10010 (JC861_10005) 2155486..2157870 - 2385 WP_107679155.1 molybdopterin-dependent oxidoreductase -
JC861_RS10015 (JC861_10010) 2158236..2158724 - 489 WP_107679156.1 RidA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-83)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13331.30 Da        Isoelectric Point: 8.8135

>T184033 WP_107679151.1 NZ_CP066140:2153289-2153633 [Morganella morganii]
VWTVLLTDYFNEWLSKQDTRMKEKVLASLGNLEIYGPVLTRPYVDTVKTSQYPNMKELRIWHAGRAIRAFFAFDPERQAI
ILCAGDKGKDKRFYQTMIRIADEQFSSYLSATQE

Download         Length: 345 bp

>T184033 NZ_CP087294:c3239351-3238953 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAACATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTGATTGAAGGTTTCGTATCTCGTTTGGAAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACT
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTAACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11166.90 Da        Isoelectric Point: 7.0156

>AT184033 WP_107679152.1 NZ_CP066140:2153638-2153937 [Morganella morganii]
MKTLQEVIAAQSPESRERIKQLTDELVLETGLQLLREELHISQKTLANNLGISQPAVTQIEQRGNDIKLATLKRYIEAMG
GTLRLTIELPTGDNRIFRV

Download         Length: 300 bp

>AT184033 NZ_CP087294:c3239578-3239351 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAGGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References