Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1693563..1694221 Replicon chromosome
Accession NZ_CP066140
Organism Morganella morganii strain FAM24670

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JC861_RS07625 Protein ID WP_107678433.1
Coordinates 1693563..1693916 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JC861_RS07630 Protein ID WP_046892450.1
Coordinates 1693919..1694221 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JC861_RS07615 (JC861_07610) 1691742..1691999 - 258 WP_107678432.1 biofilm formation regulator BssS -
JC861_RS07620 (JC861_07615) 1692234..1693286 - 1053 WP_107678459.1 dihydroorotase -
JC861_RS07625 (JC861_07620) 1693563..1693916 + 354 WP_107678433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JC861_RS07630 (JC861_07625) 1693919..1694221 + 303 WP_046892450.1 XRE family transcriptional regulator Antitoxin
JC861_RS07655 (JC861_07650) 1695348..1695857 - 510 WP_107678434.1 YlaC family protein -
JC861_RS07660 (JC861_07655) 1696315..1696527 + 213 WP_004240014.1 transcription antiterminator/RNA stability regulator CspE -
JC861_RS07665 (JC861_07660) 1696631..1696825 + 195 WP_046892448.1 protein DsrB -
JC861_RS07670 (JC861_07665) 1697177..1697872 + 696 WP_046892447.1 MgtC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13412.31 Da        Isoelectric Point: 9.7296

>T184032 WP_107678433.1 NZ_CP066140:1693563-1693916 [Morganella morganii]
VWKIITTDNFAAWFAAQDDGDRTAILAAMLVLEKTGPGLSGPYADTVKGSRYTNMKELRIQSRGQPIRAFFAFDPERRGV
LLCAGYKTGKEKRFYMQMIPQADREYTEWLNRPENRS

Download         Length: 354 bp

>T184032 NZ_CP087294:c2750848-2750597 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11093.93 Da        Isoelectric Point: 8.5490

>AT184032 WP_046892450.1 NZ_CP066140:1693919-1694221 [Morganella morganii]
MGKSLRQLLAEEKPEVAAAARVQADEILLNIHLAELREKVNKTQVEMAQALGIKQPTVAGMEKPGRDVKLSTLRRYVDAI
GGKLNIDVELPDGTHYMFRV

Download         Length: 303 bp

>AT184032 NZ_CP087294:c2750600-2750346 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References