Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1693019..1693677 Replicon chromosome
Accession NZ_CP066138
Organism Morganella morganii strain FAM24671

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JC830_RS07615 Protein ID WP_107678433.1
Coordinates 1693019..1693372 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JC830_RS07620 Protein ID WP_046892450.1
Coordinates 1693375..1693677 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JC830_RS07605 (JC830_07605) 1691198..1691455 - 258 WP_107678432.1 biofilm formation regulator BssS -
JC830_RS07610 (JC830_07610) 1691690..1692742 - 1053 WP_107678459.1 dihydroorotase -
JC830_RS07615 (JC830_07615) 1693019..1693372 + 354 WP_107678433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JC830_RS07620 (JC830_07620) 1693375..1693677 + 303 WP_046892450.1 XRE family transcriptional regulator Antitoxin
JC830_RS07645 (JC830_07645) 1694804..1695313 - 510 WP_107678434.1 YlaC family protein -
JC830_RS07650 (JC830_07650) 1695771..1695983 + 213 WP_004240014.1 transcription antiterminator/RNA stability regulator CspE -
JC830_RS07655 (JC830_07655) 1696087..1696281 + 195 WP_046892448.1 protein DsrB -
JC830_RS07660 (JC830_07660) 1696633..1697328 + 696 WP_046892447.1 MgtC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13412.31 Da        Isoelectric Point: 9.7296

>T184028 WP_107678433.1 NZ_CP066138:1693019-1693372 [Morganella morganii]
VWKIITTDNFAAWFAAQDDGDRTAILAAMLVLEKTGPGLSGPYADTVKGSRYTNMKELRIQSRGQPIRAFFAFDPERRGV
LLCAGYKTGKEKRFYMQMIPQADREYTEWLNRPENRS

Download         Length: 354 bp

>T184028 NZ_CP087294:2080121-2080297 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTGGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCAAGGGCGACGCAGTGTCATGCCGCGTCACCCCAGTGATGAGATAAAAGAACCATTGCGTAAAGCAATCCTGAAGC
AACTCGGTTTAAATTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11093.93 Da        Isoelectric Point: 8.5490

>AT184028 WP_046892450.1 NZ_CP066138:1693375-1693677 [Morganella morganii]
MGKSLRQLLAEEKPEVAAAARVQADEILLNIHLAELREKVNKTQVEMAQALGIKQPTVAGMEKPGRDVKLSTLRRYVDAI
GGKLNIDVELPDGTHYMFRV

Download         Length: 303 bp

>AT184028 NZ_CP087294:2080341-2080757 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACTCCTGCGCCGGAAGGCGGTTATGTGGTTTCTTTTGTAGATATCCCTGAAGCGTTGAC
GCAGGGAGAAACTGTTGCTGAAGCGATGGAAGCAGCAAAAGATGCCTTACTCACCGCATTTGATTTTTATTTTGAAGATA
ATGAGCTAATCCCGTTGCCTTCGCCATTAACTAACAACGATCACTTTATTGAAGTGCCTTTAAGTATCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGACGAATTGGCAAACCTAAACAGGAGAT
TACTCGCTTATTTAACTTGCACCATGCTACAAAAATCGACGCCGTCCAGCTTGCGGCTAAGGCGCTTGGCAAAGAGTTAT
CACTGGTGATGGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References