Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2237831..2238479 Replicon chromosome
Accession NZ_CP066137
Organism Morganella morganii strain FAM24672

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JC827_RS10520 Protein ID WP_107679151.1
Coordinates 2237831..2238175 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JC827_RS10525 Protein ID WP_107679152.1
Coordinates 2238180..2238479 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JC827_RS10510 (JC827_10505) 2233431..2234528 + 1098 WP_107679149.1 efflux RND transporter periplasmic adaptor subunit -
JC827_RS10515 (JC827_10510) 2234525..2237614 + 3090 WP_107679150.1 efflux RND transporter permease subunit -
JC827_RS10520 (JC827_10515) 2237831..2238175 + 345 WP_107679151.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JC827_RS10525 (JC827_10520) 2238180..2238479 + 300 WP_107679152.1 helix-turn-helix transcriptional regulator Antitoxin
JC827_RS10530 (JC827_10525) 2238533..2239405 - 873 WP_107679153.1 dimethyl sulfoxide reductase anchor subunit -
JC827_RS10535 (JC827_10530) 2239402..2240031 - 630 WP_107679154.1 dimethylsulfoxide reductase subunit B -
JC827_RS10540 (JC827_10535) 2240028..2242412 - 2385 WP_107679155.1 molybdopterin-dependent oxidoreductase -
JC827_RS10545 (JC827_10540) 2242778..2243266 - 489 WP_107679156.1 RidA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-83)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13331.30 Da        Isoelectric Point: 8.8135

>T184026 WP_107679151.1 NZ_CP066137:2237831-2238175 [Morganella morganii]
VWTVLLTDYFNEWLSKQDTRMKEKVLASLGNLEIYGPVLTRPYVDTVKTSQYPNMKELRIWHAGRAIRAFFAFDPERQAI
ILCAGDKGKDKRFYQTMIRIADEQFSSYLSATQE

Download         Length: 345 bp

>T184026 NZ_CP087294:c1773619-1773125 [Escherichia coli]
ATGATTCAGGCCCCCGAGCCACTCATGGCAAGGCATCAATTCACCTCTTTTTGCTCGGGAGTAGAAACGATGGATAACTG
GCTAAAGCAGAGAGCCCTAAAAAATCAGCTTGCCGGCGCATCACGTACATTTGTTAGCTGTGATACGTATAGCAACGTTT
TGGCATATTATTCGCTTGCTTCCAGCGCCGTTGAAACGTATGTCGCGACAGGACGATTTCGCCGAAATATGCCAGAACCG
ATCCCTGTTGTAGTACTTGGTCGTCTGGCAATAGATAAATCATTACAGGGTCAGGGCATCGATCGTGCGATGGTCAGAGA
TGCCGGTCTACGAGTACTACAGGCGGCTGAAGTCATTGGTATTCGCGGAATGTTGGTCCATGCGTTATCAGACCAGGCCC
GTGAGTTTTATCTGCGAGTGGGGTTTGAACCATCGCCTGTCGATTCTATGATACTGATGGCAACATTGGCTGATTTGCAG
GAATGTCTTAAATAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11166.90 Da        Isoelectric Point: 7.0156

>AT184026 WP_107679152.1 NZ_CP066137:2238180-2238479 [Morganella morganii]
MKTLQEVIAAQSPESRERIKQLTDELVLETGLQLLREELHISQKTLANNLGISQPAVTQIEQRGNDIKLATLKRYIEAMG
GTLRLTIELPTGDNRIFRV

Download         Length: 300 bp

>AT184026 NZ_CP087294:c1773909-1773616 [Escherichia coli]
ATGCCAGCAGCCAATAACATTCCAGCCAGGCGCGAATCTTTAAACTTGCGCATAAAACCCGCAGAACGCGATCTTATTGA
CCGGGCCGCTAAAGCCCGAGGAAAAAATCGCACCGAATTTGTCCTTGAGGCCGCCAGAGCCGCAGCTGAAGAGGCGCTCA
TTGAGCAGAGAATTTTCAGGATCGATTCTGATGATTATCAGCTATTTTTGAATCGTCTGGATCAGCCCCCCGCGCCCAAT
GCTGCATTACGCAAAACCATGCAAACACCCGCGCCGTGGGAGCAAAAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References