Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1738759..1739417 Replicon chromosome
Accession NZ_CP066137
Organism Morganella morganii strain FAM24672

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JC827_RS07890 Protein ID WP_107678433.1
Coordinates 1738759..1739112 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JC827_RS07895 Protein ID WP_046892450.1
Coordinates 1739115..1739417 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JC827_RS07880 (JC827_07880) 1736938..1737195 - 258 WP_107678432.1 biofilm formation regulator BssS -
JC827_RS07885 (JC827_07885) 1737430..1738482 - 1053 WP_107678459.1 dihydroorotase -
JC827_RS07890 (JC827_07890) 1738759..1739112 + 354 WP_107678433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JC827_RS07895 (JC827_07895) 1739115..1739417 + 303 WP_046892450.1 XRE family transcriptional regulator Antitoxin
JC827_RS07920 (JC827_07920) 1740544..1741053 - 510 WP_107678434.1 YlaC family protein -
JC827_RS07925 (JC827_07925) 1741511..1741723 + 213 WP_004240014.1 transcription antiterminator/RNA stability regulator CspE -
JC827_RS07930 (JC827_07930) 1741827..1742021 + 195 WP_046892448.1 protein DsrB -
JC827_RS07935 (JC827_07935) 1742373..1743068 + 696 WP_046892447.1 MgtC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13412.31 Da        Isoelectric Point: 9.7296

>T184025 WP_107678433.1 NZ_CP066137:1738759-1739112 [Morganella morganii]
VWKIITTDNFAAWFAAQDDGDRTAILAAMLVLEKTGPGLSGPYADTVKGSRYTNMKELRIQSRGQPIRAFFAFDPERRGV
LLCAGYKTGKEKRFYMQMIPQADREYTEWLNRPENRS

Download         Length: 354 bp

>T184025 NZ_CP087294:c1526548-1526162 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11093.93 Da        Isoelectric Point: 8.5490

>AT184025 WP_046892450.1 NZ_CP066137:1739115-1739417 [Morganella morganii]
MGKSLRQLLAEEKPEVAAAARVQADEILLNIHLAELREKVNKTQVEMAQALGIKQPTVAGMEKPGRDVKLSTLRRYVDAI
GGKLNIDVELPDGTHYMFRV

Download         Length: 303 bp

>AT184025 NZ_CP087294:c1526172-1525843 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References