Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2137217..2137865 Replicon chromosome
Accession NZ_CP066133
Organism Morganella morganii strain FAM24675

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JC826_RS09825 Protein ID WP_107679151.1
Coordinates 2137217..2137561 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JC826_RS09830 Protein ID WP_107679152.1
Coordinates 2137566..2137865 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JC826_RS09815 (JC826_09820) 2132817..2133914 + 1098 WP_107679149.1 efflux RND transporter periplasmic adaptor subunit -
JC826_RS09820 (JC826_09825) 2133911..2137000 + 3090 WP_107679150.1 efflux RND transporter permease subunit -
JC826_RS09825 (JC826_09830) 2137217..2137561 + 345 WP_107679151.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JC826_RS09830 (JC826_09835) 2137566..2137865 + 300 WP_107679152.1 helix-turn-helix transcriptional regulator Antitoxin
JC826_RS09835 (JC826_09840) 2137919..2138791 - 873 WP_107679153.1 dimethyl sulfoxide reductase anchor subunit -
JC826_RS09840 (JC826_09845) 2138788..2139417 - 630 WP_107679154.1 dimethylsulfoxide reductase subunit B -
JC826_RS09845 (JC826_09850) 2139414..2141798 - 2385 WP_107679155.1 molybdopterin-dependent oxidoreductase -
JC826_RS09850 (JC826_09855) 2142164..2142652 - 489 WP_107679156.1 RidA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-83)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13331.30 Da        Isoelectric Point: 8.8135

>T184022 WP_107679151.1 NZ_CP066133:2137217-2137561 [Morganella morganii]
VWTVLLTDYFNEWLSKQDTRMKEKVLASLGNLEIYGPVLTRPYVDTVKTSQYPNMKELRIWHAGRAIRAFFAFDPERQAI
ILCAGDKGKDKRFYQTMIRIADEQFSSYLSATQE

Download         Length: 345 bp

>T184022 NZ_CP087294:c847803-847426 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCAACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCAGGATTC
AGCGCTTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCAG
CAACTACAGAATGGTGAACGACATCATCCGGGGTGAACATTCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11166.90 Da        Isoelectric Point: 7.0156

>AT184022 WP_107679152.1 NZ_CP066133:2137566-2137865 [Morganella morganii]
MKTLQEVIAAQSPESRERIKQLTDELVLETGLQLLREELHISQKTLANNLGISQPAVTQIEQRGNDIKLATLKRYIEAMG
GTLRLTIELPTGDNRIFRV

Download         Length: 300 bp

>AT184022 NZ_CP087294:c848224-847850 [Escherichia coli]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCATCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References