Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1688732..1689390 Replicon chromosome
Accession NZ_CP066133
Organism Morganella morganii strain FAM24675

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JC826_RS07585 Protein ID WP_107678433.1
Coordinates 1688732..1689085 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JC826_RS07590 Protein ID WP_046892450.1
Coordinates 1689088..1689390 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JC826_RS07575 (JC826_07580) 1686911..1687168 - 258 WP_107678432.1 biofilm formation regulator BssS -
JC826_RS07580 (JC826_07585) 1687403..1688455 - 1053 WP_107678459.1 dihydroorotase -
JC826_RS07585 (JC826_07590) 1688732..1689085 + 354 WP_107678433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JC826_RS07590 (JC826_07595) 1689088..1689390 + 303 WP_046892450.1 XRE family transcriptional regulator Antitoxin
JC826_RS07615 (JC826_07620) 1690517..1691026 - 510 WP_107678434.1 YlaC family protein -
JC826_RS07620 (JC826_07625) 1691484..1691696 + 213 WP_004240014.1 transcription antiterminator/RNA stability regulator CspE -
JC826_RS07625 (JC826_07630) 1691800..1691994 + 195 WP_046892448.1 protein DsrB -
JC826_RS07630 (JC826_07635) 1692346..1693041 + 696 WP_046892447.1 MgtC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13412.31 Da        Isoelectric Point: 9.7296

>T184021 WP_107678433.1 NZ_CP066133:1688732-1689085 [Morganella morganii]
VWKIITTDNFAAWFAAQDDGDRTAILAAMLVLEKTGPGLSGPYADTVKGSRYTNMKELRIQSRGQPIRAFFAFDPERRGV
LLCAGYKTGKEKRFYMQMIPQADREYTEWLNRPENRS

Download         Length: 354 bp

>T184021 NZ_CP087294:500983-501360 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGTGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCAGGATTC
AGCACCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
TAACTACAGAACGATAAATAACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11093.93 Da        Isoelectric Point: 8.5490

>AT184021 WP_046892450.1 NZ_CP066133:1689088-1689390 [Morganella morganii]
MGKSLRQLLAEEKPEVAAAARVQADEILLNIHLAELREKVNKTQVEMAQALGIKQPTVAGMEKPGRDVKLSTLRRYVDAI
GGKLNIDVELPDGTHYMFRV

Download         Length: 303 bp

>AT184021 NZ_CP087294:500526-500894 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGTACCATCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACCGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References