Detailed information of TA system TA184021

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 1688732..1689390
• Replicon: chromosome
• Accession: NZ_CP066133
• Organism: Morganella morganii strain FAM24675

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: JC826_RS07585
• Protein ID: WP_107678433.1
• Coordinates: 1688732..1689085 (+)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: JC826_RS07590
• Protein ID: WP_046892450.1
• Coordinates: 1689088..1689390 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JC826_RS07575 (JC826_07580)	1686911..1687168	-	258	WP_107678432.1	biofilm formation regulator BssS	-
JC826_RS07580 (JC826_07585)	1687403..1688455	-	1053	WP_107678459.1	dihydroorotase	-
JC826_RS07585 (JC826_07590)	1688732..1689085	+	354	WP_107678433.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JC826_RS07590 (JC826_07595)	1689088..1689390	+	303	WP_046892450.1	XRE family transcriptional regulator	Antitoxin
JC826_RS07615 (JC826_07620)	1690517..1691026	-	510	WP_107678434.1	YlaC family protein	-
JC826_RS07620 (JC826_07625)	1691484..1691696	+	213	WP_004240014.1	transcription antiterminator/RNA stability regulator CspE	-
JC826_RS07625 (JC826_07630)	1691800..1691994	+	195	WP_046892448.1	protein DsrB	-
JC826_RS07630 (JC826_07635)	1692346..1693041	+	696	WP_046892447.1	MgtC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (33-81)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13412.31 Da
• Isoelectric Point: 9.7296

>T184021 WP_107678433.1 NZ_CP066133:1688732-1689085 [Morganella morganii]
VWKIITTDNFAAWFAAQDDGDRTAILAAMLVLEKTGPGLSGPYADTVKGSRYTNMKELRIQSRGQPIRAFFAFDPERRGV
LLCAGYKTGKEKRFYMQMIPQADREYTEWLNRPENRS

Nucleotide

• Length: 354 bp

>T184021 NZ_CP087294:500983-501360 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGTGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCAGGATTC
AGCACCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
TAACTACAGAACGATAAATAACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11093.93 Da
• Isoelectric Point: 8.5490

>AT184021 WP_046892450.1 NZ_CP066133:1689088-1689390 [Morganella morganii]
MGKSLRQLLAEEKPEVAAAARVQADEILLNIHLAELREKVNKTQVEMAQALGIKQPTVAGMEKPGRDVKLSTLRRYVDAI
GGKLNIDVELPDGTHYMFRV

Nucleotide

• Length: 303 bp

>AT184021 NZ_CP087294:500526-500894 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGTACCATCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACCGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA