Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1640265..1640923 Replicon chromosome
Accession NZ_CP066132
Organism Morganella morganii strain FAM24676

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JC825_RS07380 Protein ID WP_107678433.1
Coordinates 1640265..1640618 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JC825_RS07385 Protein ID WP_046892450.1
Coordinates 1640621..1640923 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JC825_RS07370 (JC825_07375) 1638444..1638701 - 258 WP_107678432.1 biofilm formation regulator BssS -
JC825_RS07375 (JC825_07380) 1638936..1639988 - 1053 WP_218455411.1 dihydroorotase -
JC825_RS07380 (JC825_07385) 1640265..1640618 + 354 WP_107678433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JC825_RS07385 (JC825_07390) 1640621..1640923 + 303 WP_046892450.1 XRE family transcriptional regulator Antitoxin
JC825_RS07410 (JC825_07415) 1642051..1642560 - 510 WP_107678434.1 YlaC family protein -
JC825_RS07415 (JC825_07420) 1643019..1643231 + 213 WP_004240014.1 transcription antiterminator/RNA stability regulator CspE -
JC825_RS07420 (JC825_07425) 1643335..1643529 + 195 WP_046892448.1 protein DsrB -
JC825_RS07425 (JC825_07430) 1643881..1644576 + 696 WP_046892447.1 MgtC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13412.31 Da        Isoelectric Point: 9.7296

>T184018 WP_107678433.1 NZ_CP066132:1640265-1640618 [Morganella morganii]
VWKIITTDNFAAWFAAQDDGDRTAILAAMLVLEKTGPGLSGPYADTVKGSRYTNMKELRIQSRGQPIRAFFAFDPERRGV
LLCAGYKTGKEKRFYMQMIPQADREYTEWLNRPENRS

Download         Length: 354 bp

>T184018 NZ_CP087291:c92215-92066 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11093.93 Da        Isoelectric Point: 8.5490

>AT184018 WP_046892450.1 NZ_CP066132:1640621-1640923 [Morganella morganii]
MGKSLRQLLAEEKPEVAAAARVQADEILLNIHLAELREKVNKTQVEMAQALGIKQPTVAGMEKPGRDVKLSTLRRYVDAI
GGKLNIDVELPDGTHYMFRV

Download         Length: 303 bp

>AT184018 NZ_CP087291:92259-92320 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References