Detailed information of TA system TA184017

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 859505..860103
• Replicon: chromosome
• Accession: NZ_CP066132
• Organism: Morganella morganii strain FAM24676

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: JC825_RS03770
• Protein ID: WP_052926456.1
• Coordinates: 859505..859783 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: JC825_RS03775
• Protein ID: WP_218455095.1
• Coordinates: 859783..860103 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JC825_RS03765 (JC825_03770)	856869..859373	+	2505	WP_218455094.1	bifunctional glycosyl transferase/transpeptidase	-
JC825_RS03770 (JC825_03775)	859505..859783	+	279	WP_052926456.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JC825_RS03775 (JC825_03780)	859783..860103	+	321	WP_218455095.1	HigA family addiction module antitoxin	Antitoxin
JC825_RS03780 (JC825_03785)	860163..860819	-	657	WP_052926391.1	formate dehydrogenase-N subunit gamma	-
JC825_RS03785 (JC825_03790)	860812..861702	-	891	WP_052926392.1	formate dehydrogenase subunit beta	-
JC825_RS03790 (JC825_03795)	861712..864759	-	3048	WP_218455096.1	formate dehydrogenase-N subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (3-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (7-81)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10665.24 Da
• Isoelectric Point: 8.5628

>T184017 WP_052926456.1 NZ_CP066132:859505-859783 [Morganella morganii]
MIKSFKHKGLKQLFENGVISGIPAQDAVRINDRLQAIDSATMIDDLNIHIYKLHPLRGDRVGIWSITVRANWRITFEFRN
GDAYILNLEDYH

Nucleotide

• Length: 279 bp

>T184017 NZ_CP087291:c88683-88396 [Escherichia coli]
ATGACTTATACGGTAAAATTCAGGGATGATGCGCTCAAGGAATGGCTGAAACTGGATAAGACCATTCAACAACAGTTTGT
GAAAAAACTAAAAAAATGCAGCGAAAATCCTCATATACCGTCAGCAAAACTAAGAGGGCTAAAGGATTGCTACAAAATTA
AACTACGTGCATCGGGATTTCGTCTGGTTTATCAGGTGATTGACGATATGTTAATTATTGCGGTTGTTGCGGTAGGAAAA
CGAGAACGTAGTAACGTTTATAATCTCGCCAGTGAGAGAATGAGATAG

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 11240.85 Da
• Isoelectric Point: 7.1637

>AT184017 WP_218455095.1 NZ_CP066132:859783-860103 [Morganella morganii]
MKQAIVSHPGTIVANILTDLGVGVRQFAGNIGVTPATVSRFLSGKTALTPALAIRIAAALGSNPAFWLRLQANYDLHRLE
KEIDISGITLYGSSEEDGFCNTSPDK

Nucleotide

• Length: 321 bp

>AT184017 NZ_CP087291:c88931-88680 [Escherichia coli]
ATGCCTAACATCATTCTGTCTGACACCAGTGCAAGTGTCAGTGAACTGAAAAAAAATCCTATGGCTACAGTCAGTGCCGG
AGATGGTTACCCTGTCGCCATTCTTAACCGGAATCAGCCGGCATTCTACTGTGTGCCTGCTGAACTGTATGAAAGGATGC
TTGATGCTCTGGATGACCAGGAACTGGTGAAACTGGTTACTGAACGCAGCAATCAGCCACTGCATGATGTGGACCTAGAC
AGTTATTTATGA