Detailed information of TA system TA184009

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 1646038..1646696
• Replicon: chromosome
• Accession: NZ_CP066129
• Organism: Morganella morganii strain FAM24679

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A1M7JR40
• Locus tag: JC793_RS07450
• Protein ID: WP_072871765.1
• Coordinates: 1646038..1646391 (+)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: JC793_RS07455
• Protein ID: WP_046892450.1
• Coordinates: 1646394..1646696 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JC793_RS07440 (JC793_07440)	1644217..1644474	-	258	WP_024473889.1	biofilm formation regulator BssS	-
JC793_RS07445 (JC793_07445)	1644709..1645761	-	1053	WP_218428020.1	dihydroorotase	-
JC793_RS07450 (JC793_07450)	1646038..1646391	+	354	WP_072871765.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JC793_RS07455 (JC793_07455)	1646394..1646696	+	303	WP_046892450.1	XRE family transcriptional regulator	Antitoxin
JC793_RS07480 (JC793_07480)	1647824..1648333	-	510	WP_166707496.1	YlaC family protein	-
JC793_RS07485 (JC793_07485)	1648792..1649004	+	213	WP_004240014.1	transcription antiterminator/RNA stability regulator CspE	-
JC793_RS07490 (JC793_07490)	1649108..1649302	+	195	WP_046892448.1	protein DsrB	-
JC793_RS07495 (JC793_07495)	1649654..1650349	+	696	WP_046892447.1	MgtC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (33-81)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13569.48 Da
• Isoelectric Point: 9.7291

>T184009 WP_072871765.1 NZ_CP066129:1646038-1646391 [Morganella morganii]
VWKIITTDNFAAWFAEQDDGDRTAILAAMLVLEKTGPGLSRPYADTVKGSRYTNMKELRIQSRGQPIRAFFAFDPERRGV
LLCAGYKTGKEKRFYMQMIPQADREYTEWLNRPENRS

Nucleotide

• Length: 354 bp

>T184009 NZ_CP087290:c4388982-4388488 [Escherichia coli]
ATGATTCAGGCCCCCGAGCCACTCATGGCAAGGCATCAATTCACCTCTTTTTGCTCGGGAGTAGAAACGATGGATAACTG
GCTAAAGCAGAGAGCCCTAAAAAATCAGCTTGCCGGCGCATCACGTACATTTGTTAGCTGTGATACGTATAGCAACGTTT
TGGCATATTATTCGCTTGCTTCCAGCGCCGTTGAAACGTATGTCGCGACAGGACGATTTCGCCGAAATATGCCAGAACCG
ATCCCTGTTGTAGTACTTGGTCGTCTGGCAATAGATAAATCATTACAGGGTCAGGGCATCGATCGTGCGATGGTCAGAGA
TGCCGGTCTACGAGTACTACAGGCGGCTGAAGTCATTGGTATTCGCGGAATGTTGGTCCATGCGTTATCAGACCAGGCCC
GTGAGTTTTATCTGCGAGTGGGGTTTGAACCATCGCCTGTCGATTCTATGATACTGATGGCAACATTGGCTGATTTGCAG
GAATGTCTTAAATAG

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11093.93 Da
• Isoelectric Point: 8.5490

>AT184009 WP_046892450.1 NZ_CP066129:1646394-1646696 [Morganella morganii]
MGKSLRQLLAEEKPEVAAAARVQADEILLNIHLAELREKVNKTQVEMAQALGIKQPTVAGMEKPGRDVKLSTLRRYVDAI
GGKLNIDVELPDGTHYMFRV

Nucleotide

• Length: 303 bp

>AT184009 NZ_CP087290:c4389272-4388979 [Escherichia coli]
ATGCCAGCAGCCAATAACATTCCAGCCAGGCGCGAATCTTTAAACTTGCGCATAAAACCCGCAGAACGCGATCTTATTGA
CCGGGCCGCTAAAGCCCGAGGAAAAAATCGCACCGAATTTGTCCTTGAGGCCGCCAGAGCCGCAGCTGAAGAGGCGCTCA
TTGAGCAGAGAATTTTCAGGATCGATTCTGATGATTATCAGCTATTTTTGAATCGTCTGGATCAGCCCCCCGCGCCCAAT
GCTGCATTACGCAAAACCATGCAAACACCCGCGCCGTGGGAGCAAAAAAAATGA

Structures

Toxin

• AlphaFold DB: A0A1M7JR40