Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2134399..2135047 Replicon chromosome
Accession NZ_CP066127
Organism Morganella morganii strain FAM24685

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JA116_RS09925 Protein ID WP_107679151.1
Coordinates 2134399..2134743 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JA116_RS09930 Protein ID WP_107679152.1
Coordinates 2134748..2135047 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JA116_RS09915 (JA116_09915) 2129999..2131096 + 1098 WP_107679149.1 efflux RND transporter periplasmic adaptor subunit -
JA116_RS09920 (JA116_09920) 2131093..2134182 + 3090 WP_107679150.1 efflux RND transporter permease subunit -
JA116_RS09925 (JA116_09925) 2134399..2134743 + 345 WP_107679151.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JA116_RS09930 (JA116_09930) 2134748..2135047 + 300 WP_107679152.1 helix-turn-helix transcriptional regulator Antitoxin
JA116_RS09935 (JA116_09935) 2135101..2135973 - 873 WP_107679153.1 dimethyl sulfoxide reductase anchor subunit -
JA116_RS09940 (JA116_09940) 2135970..2136599 - 630 WP_107679154.1 dimethylsulfoxide reductase subunit B -
JA116_RS09945 (JA116_09945) 2136596..2138980 - 2385 WP_107679155.1 molybdopterin-dependent oxidoreductase -
JA116_RS09950 (JA116_09950) 2139346..2139834 - 489 WP_107679156.1 RidA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-83)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13331.30 Da        Isoelectric Point: 8.8135

>T184006 WP_107679151.1 NZ_CP066127:2134399-2134743 [Morganella morganii]
VWTVLLTDYFNEWLSKQDTRMKEKVLASLGNLEIYGPVLTRPYVDTVKTSQYPNMKELRIWHAGRAIRAFFAFDPERQAI
ILCAGDKGKDKRFYQTMIRIADEQFSSYLSATQE

Download         Length: 345 bp

>T184006 NZ_CP087290:c3714656-3714438 [Escherichia coli]
ATGTCCGAAAAACCTTTAACAAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11166.90 Da        Isoelectric Point: 7.0156

>AT184006 WP_107679152.1 NZ_CP066127:2134748-2135047 [Morganella morganii]
MKTLQEVIAAQSPESRERIKQLTDELVLETGLQLLREELHISQKTLANNLGISQPAVTQIEQRGNDIKLATLKRYIEAMG
GTLRLTIELPTGDNRIFRV

Download         Length: 300 bp

>AT184006 NZ_CP087290:c3715056-3714682 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCGCAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References