Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1689324..1689982 Replicon chromosome
Accession NZ_CP066127
Organism Morganella morganii strain FAM24685

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JA116_RS07630 Protein ID WP_107678433.1
Coordinates 1689324..1689677 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JA116_RS07635 Protein ID WP_046892450.1
Coordinates 1689680..1689982 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JA116_RS07620 (JA116_07620) 1687502..1687759 - 258 WP_107678432.1 biofilm formation regulator BssS -
JA116_RS07625 (JA116_07625) 1687995..1689047 - 1053 WP_107678459.1 dihydroorotase -
JA116_RS07630 (JA116_07630) 1689324..1689677 + 354 WP_107678433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JA116_RS07635 (JA116_07635) 1689680..1689982 + 303 WP_046892450.1 XRE family transcriptional regulator Antitoxin
JA116_RS07660 (JA116_07660) 1691109..1691618 - 510 WP_107678434.1 YlaC family protein -
JA116_RS07665 (JA116_07665) 1692076..1692288 + 213 WP_004240014.1 transcription antiterminator/RNA stability regulator CspE -
JA116_RS07670 (JA116_07670) 1692393..1692587 + 195 WP_046892448.1 protein DsrB -
JA116_RS07675 (JA116_07675) 1692939..1693634 + 696 WP_046892447.1 MgtC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13412.31 Da        Isoelectric Point: 9.7296

>T184005 WP_107678433.1 NZ_CP066127:1689324-1689677 [Morganella morganii]
VWKIITTDNFAAWFAAQDDGDRTAILAAMLVLEKTGPGLSGPYADTVKGSRYTNMKELRIQSRGQPIRAFFAFDPERRGV
LLCAGYKTGKEKRFYMQMIPQADREYTEWLNRPENRS

Download         Length: 354 bp

>T184005 NZ_CP087290:c3407581-3407204 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCAACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCTTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCAG
CAACTACAGAATGGTGAACGACATCATCCGGGGTGAACATTCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11093.93 Da        Isoelectric Point: 8.5490

>AT184005 WP_046892450.1 NZ_CP066127:1689680-1689982 [Morganella morganii]
MGKSLRQLLAEEKPEVAAAARVQADEILLNIHLAELREKVNKTQVEMAQALGIKQPTVAGMEKPGRDVKLSTLRRYVDAI
GGKLNIDVELPDGTHYMFRV

Download         Length: 303 bp

>AT184005 NZ_CP087290:c3408002-3407628 [Escherichia coli]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCATCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References