183979

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 41906..42557 Replicon plasmid unnamed map unlocalized
Accession NZ_CP066122
Organism Acinetobacter bereziniae strain GD0320

Toxin (Protein)


Gene name higB Uniprot ID N9BC17
Locus tag I9190_RS21735 Protein ID WP_004967307.1
Coordinates 42201..42557 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag I9190_RS21730 Protein ID WP_001140620.1
Coordinates 41906..42208 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I9190_RS21705 (I9190_21705) 37050..37640 - 591 WP_000058345.1 TetR/AcrR family transcriptional regulator -
I9190_RS21710 (I9190_21710) 37733..38572 + 840 WP_001058024.1 alpha/beta fold hydrolase -
I9190_RS21715 (I9190_21715) 38597..39136 + 540 WP_002055813.1 hypothetical protein -
I9190_RS21720 (I9190_21720) 39183..39443 + 261 Protein_36 integrase core domain-containing protein -
I9190_RS21725 (I9190_21725) 39525..41480 + 1956 WP_000693745.1 alkyl sulfatase dimerization domain-containing protein -
I9190_RS21730 (I9190_21730) 41906..42208 - 303 WP_001140620.1 XRE family transcriptional regulator Antitoxin
I9190_RS21735 (I9190_21735) 42201..42557 - 357 WP_004967307.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I9190_RS21740 (I9190_21740) 42778..43614 - 837 WP_000480968.1 aminoglycoside O-phosphotransferase APH(6)-Id -
I9190_RS21745 (I9190_21745) 43614..44417 - 804 WP_001082319.1 aminoglycoside O-phosphotransferase APH(3'')-Ib -
I9190_RS21750 (I9190_21750) 44493..45425 - 933 WP_086374392.1 IS5 family transposase -
I9190_RS21755 (I9190_21755) 45475..45687 - 213 Protein_43 phosphoglucosamine mutase -
I9190_RS21760 (I9190_21760) 45774..46589 - 816 WP_001043260.1 sulfonamide-resistant dihydropteroate synthase Sul2 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aph(6)-Id / aph(3'')-Ib / sul2 / cmlB1 / mph(E) / msr(E) / blaOXA-58 - 1..122921 122921
- inside IScluster/Tn aph(6)-Id / aph(3'')-Ib / sul2 / cmlB1 - 35613..53175 17562


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

HigA2-like, helix-turn-helix domain

(14-89)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13601.62 Da        Isoelectric Point: 6.4648

>T183979 WP_004967307.1 NZ_CP066122:c42557-42201 [Acinetobacter bereziniae]
MWIVITTDLFNEWLEQQDESTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIADKGSKKRFYKDMLDIADEQYQLHLTTLGDKSNG

Download         Length: 357 bp

>T183979 NZ_CP087287:c4660337-4660230 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCACGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11227.02 Da        Isoelectric Point: 6.4759

>AT183979 WP_001140620.1 NZ_CP066122:c42208-41906 [Acinetobacter bereziniae]
MAKTLQELLASRSPESQARIQKMADELLLENQLHLIREELEISQKELAETLGIKQPSLSAIENRGNDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Download         Length: 303 bp

>AT183979 NZ_CP087287:4660385-4660451 [Escherichia coli]
GGTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T4TW67

Antitoxin

Source ID Structure

References