Detailed information of TA system TA183978

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 2124548..2125133
• Replicon: chromosome
• Accession: NZ_CP066121
• Organism: Acinetobacter bereziniae strain GD0320

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: I9190_RS09740
• Protein ID: WP_121774457.1
• Coordinates: 2124813..2125133 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A8I1A8A3
• Locus tag: I9190_RS09735
• Protein ID: WP_058971122.1
• Coordinates: 2124548..2124820 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I9190_RS09720	2120252..2122453	-	2202	WP_100885315.1	glycerol-3-phosphate 1-O-acyltransferase PlsB	-
I9190_RS09725	2122687..2123685	+	999	WP_042088689.1	cysteine synthase A	-
I9190_RS09730	2123960..2124466	-	507	WP_121774458.1	ATP-binding protein	-
I9190_RS09735	2124548..2124820	-	273	WP_058971122.1	helix-turn-helix domain-containing protein	Antitoxin
I9190_RS09740	2124813..2125133	-	321	WP_121774457.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I9190_RS09745	2125518..2126054	-	537	WP_042088690.1	lytic transglycosylase domain-containing protein	-
I9190_RS09750	2126918..2129542	+	2625	WP_200232582.1	type VI secretion system tip protein VgrG	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (40-102)

Antitoxin

• Cro/C1-type helix-turn-helix domain (37-75)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12187.02 Da
• Isoelectric Point: 7.1644

>T183978 WP_121774457.1 NZ_CP066121:c2125133-2124813 [Acinetobacter bereziniae]
MLFIETSIFTKQIKELVTDDEYRQLQQDLLVEPDKGDVIKNGGGIRKVRCAQGNKAKSGGIRVIYYWVSEDDHIFFLVAY
PKSMKDNLTDKETAILRQLVKEQLHG

Nucleotide

• Length: 321 bp

>T183978 NZ_CP087287:c4659854-4659747 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10135.62 Da
• Isoelectric Point: 9.9218

>AT183978 WP_058971122.1 NZ_CP066121:c2124820-2124548 [Acinetobacter bereziniae]
MDNTLFDDLVSSIKEAGAIKRKEIQASRVTELVLPNIKDVREKTGLSQNEFAARLHISPRTLQNWEQGRRYPTGPAATLI
RILDAHPTLI

Nucleotide

• Length: 273 bp

>AT183978 NZ_CP087287:4659911-4659968 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT