Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4511004..4511606 Replicon chromosome
Accession NZ_CP066108
Organism Enterobacter hormaechei strain Eho-7

Toxin (Protein)


Gene name higB Uniprot ID F5RRB8
Locus tag GVI68_RS21580 Protein ID WP_006808714.1
Coordinates 4511295..4511606 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID F5RRB7
Locus tag GVI68_RS21575 Protein ID WP_006808713.1
Coordinates 4511004..4511294 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GVI68_RS21560 (GVI68_21490) 4508502..4509404 + 903 WP_003861960.1 formate dehydrogenase subunit beta -
GVI68_RS21565 (GVI68_21495) 4509401..4510036 + 636 WP_006808711.1 formate dehydrogenase cytochrome b556 subunit -
GVI68_RS21570 (GVI68_21500) 4510033..4510962 + 930 WP_006808712.1 formate dehydrogenase accessory protein FdhE -
GVI68_RS21575 (GVI68_21505) 4511004..4511294 - 291 WP_006808713.1 NadS family protein Antitoxin
GVI68_RS21580 4511295..4511606 - 312 WP_006808714.1 hypothetical protein Toxin
GVI68_RS21585 (GVI68_21515) 4511755..4512696 - 942 WP_032673470.1 fatty acid biosynthesis protein FabY -
GVI68_RS21590 (GVI68_21520) 4512741..4513178 - 438 WP_006808716.1 D-aminoacyl-tRNA deacylase -
GVI68_RS21595 (GVI68_21525) 4513175..4514056 - 882 WP_003861949.1 virulence factor BrkB family protein -
GVI68_RS21600 (GVI68_21530) 4514050..4514649 - 600 WP_000965688.1 glucose-1-phosphatase -
GVI68_RS21605 (GVI68_21535) 4514768..4515568 - 801 WP_032673471.1 DeoR/GlpR family DNA-binding transcription regulator -
GVI68_RS21610 (GVI68_21540) 4515603..4516499 - 897 WP_032673472.1 sugar kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12275.30 Da        Isoelectric Point: 9.9930

>T183972 WP_006808714.1 NZ_CP066108:c4511606-4511295 [Enterobacter hormaechei]
MLFIETDIFTEDVKTLLDDDEYHRFQIFLATQPEYGDLIQNTGGLRKIRWLAGGKGKRGGVRVIYFHRTREFEIRLLLIY
RKGIKDDLSAREKAILKKMIERW

Download         Length: 312 bp

>T183972 NZ_CP087287:c2614615-2614513 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10721.23 Da        Isoelectric Point: 10.5888

>AT183972 WP_006808713.1 NZ_CP066108:c4511294-4511004 [Enterobacter hormaechei]
MEKALFERLTQSIAQMNEIAEGQREPSRTFQIDAMKIKEIRQASGLSQSKFANLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVITALSQ

Download         Length: 291 bp

>AT183972 NZ_CP087287:2614475-2614743 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F5RRB8

Antitoxin

Source ID Structure
AlphaFold DB A0A7T1QN46

References