Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4512104..4512706 Replicon chromosome
Accession NZ_CP066101
Organism Enterobacter hormaechei strain Eho-8

Toxin (Protein)


Gene name higB Uniprot ID F5RRB8
Locus tag GVI69_RS21590 Protein ID WP_006808714.1
Coordinates 4512395..4512706 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID F5RRB7
Locus tag GVI69_RS21585 Protein ID WP_006808713.1
Coordinates 4512104..4512394 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GVI69_RS21570 (GVI69_21500) 4509602..4510504 + 903 WP_003861960.1 formate dehydrogenase subunit beta -
GVI69_RS21575 (GVI69_21505) 4510501..4511136 + 636 WP_006808711.1 formate dehydrogenase cytochrome b556 subunit -
GVI69_RS21580 (GVI69_21510) 4511133..4512062 + 930 WP_006808712.1 formate dehydrogenase accessory protein FdhE -
GVI69_RS21585 (GVI69_21515) 4512104..4512394 - 291 WP_006808713.1 NadS family protein Antitoxin
GVI69_RS21590 4512395..4512706 - 312 WP_006808714.1 hypothetical protein Toxin
GVI69_RS21595 (GVI69_21525) 4512855..4513796 - 942 WP_032673470.1 fatty acid biosynthesis protein FabY -
GVI69_RS21600 (GVI69_21530) 4513841..4514278 - 438 WP_006808716.1 D-aminoacyl-tRNA deacylase -
GVI69_RS21605 (GVI69_21535) 4514275..4515156 - 882 WP_003861949.1 virulence factor BrkB family protein -
GVI69_RS21610 (GVI69_21540) 4515150..4515749 - 600 WP_000965688.1 glucose-1-phosphatase -
GVI69_RS21615 (GVI69_21545) 4515868..4516668 - 801 WP_032673471.1 DeoR/GlpR family DNA-binding transcription regulator -
GVI69_RS21620 (GVI69_21550) 4516703..4517599 - 897 WP_032673472.1 sugar kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12275.30 Da        Isoelectric Point: 9.9930

>T183953 WP_006808714.1 NZ_CP066101:c4512706-4512395 [Enterobacter hormaechei]
MLFIETDIFTEDVKTLLDDDEYHRFQIFLATQPEYGDLIQNTGGLRKIRWLAGGKGKRGGVRVIYFHRTREFEIRLLLIY
RKGIKDDLSAREKAILKKMIERW

Download         Length: 312 bp

>T183953 NZ_CP087280:c2268687-2267377 [Leclercia adecarboxylata]
ATGCGCGCACAACGACTGACTGTTGCGATGAATGGCGACGTAGTGGGTACGCTGCATCGTGACGGCAGCGGGGCGATGTC
CTTCCAGTATGCCCCGGAGTGGCTGGCCGAGCCGGGTTCGCGCGCGATTTCGCTCTCTTTACCACTACAGCACGGCAGGA
TCAGAGGCGCGCAGGTCTTTAATTTCTTCAGTAATCTGCTGCCTGACTCCGAAGCGATTATTGCCCGCATGCAGGCCCGA
TTCCAGGTTGAAACCGCTCATCCCTTTGATCTGCTGGCCAGTGTCGGGCGTGACTGTGTGGGCGCCATTCAGCTCTATCC
GCCGGGACAGGAGATCCCCCCGGTAACAGATATCGTGGCCGAACCGCTGGATGACGATCAGATTGCCGCGCTGCTCGACG
GGTATCAGATGGCACCGCTGGGGATGACCGAGGAGGATGCCGACTTTCGCATTTCGCTGGCCGGCGCGCAGGAAAAGACG
GCGCTGCTATGGTACCAGGCACGCTGGCAGCGGCCCCAGGGTAGCACCCCAACCAGTCACATCTTTAAGCTGCCGATCGG
CAGAATAGAACAAAACAATATCGACCTGAGCGAAAGTTGTGAAAACGAATGGCTGTGTTTGCGCATTGCCAAAGCCTTTG
GTTTCCCAGTAGCACAGGCGGAGATGGCAACCTTTGGCCGCAAGAAAGTGCTCATTATCGAGCGTTTCGACCGTCGCTGG
TCCAGCAGCGGGTGGCTGATGCGCCTGCCGCAGGAAGATTTTTGCCAGGCCCTGGGCGTGTCGCCAGCGCTGAAATATGA
ATCTCACGGTGGTCCCGGGATTGCCGATGCCATGAAGCTGCTGCTCGGTTCCCGCCTGGCGGGGCAGGATCGCGAGCTGT
TCTTTAAGGCGCAGATCCTGTTCTGGATGCTGGCCGCCATTGATGGTCACGGGAAGAATTTCAGCCTGTTTATCGAGGCG
GATTCCGCCTTTCGCATGGCCCCGCTGTACGACGTGATTTCCGCGTTTCCGCTGTTCGACGCAGGGGGGATCCCGGTCAA
AAAAGCCAAGATGGCGATGGCGTTACAGGGCAAGAACCGGCAGTACCATTTTGCGATGATCCAACCGCGTCACTTTATCA
GCACCGCAGCTTTTGCGGGGTATTCCCAGGAGGCCGCTCGCCGTTTGCTGGCCGAGATGGCGGAGCGAACAGACGACGTT
ATTGCCTCCGTCAGGGCAGAATTGCCACCGGATTTCCCCGCGCAGGTCAGTGAGGCCATTTTTAAGGGTTTAGCCAGCCA
GGCGGCAAGAATAGGGCGGTTCGTGAGTTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10721.23 Da        Isoelectric Point: 10.5888

>AT183953 WP_006808713.1 NZ_CP066101:c4512394-4512104 [Enterobacter hormaechei]
MEKALFERLTQSIAQMNEIAEGQREPSRTFQIDAMKIKEIRQASGLSQSKFANLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVITALSQ

Download         Length: 291 bp

>AT183953 NZ_CP087280:c2268942-2268691 [Leclercia adecarboxylata]
ATGAAAGTTACATCGGCAGACGCACTGGCTCAGGCTGTCCGGGATCAGCGTAAGGTCAATAAGTTAACCCAAACGGCAAC
GGCTGAACAGGTGGGGATTAAACAAACCACGGTATCGGAATTCGAGAACAAACCAGGCTCTACCAAACTGGAAACCTTGT
TCAAAATCCTCTCGGCGCTGGATCTGGAGCTGCACGTGGTGAAACGAGGCGGCACGCTGCCGGATAACAATGCCTGGAAG
AAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F5RRB8

Antitoxin

Source ID Structure
AlphaFold DB A0A7T1QN46

References