Detailed information of TA system TA183916

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 276469..276981
• Replicon: chromosome
• Accession: NZ_CP066093
• Organism: Streptococcus salivarius strain FDAARGOS_1045

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: I6I02_RS01385
• Protein ID: WP_198463662.1
• Coordinates: 276727..276981 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A2I1TMD2
• Locus tag: I6I02_RS01380
• Protein ID: WP_060971904.1
• Coordinates: 276469..276723 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6I02_RS01345	271532..271849	+	318	WP_002884193.1	ribosome assembly RNA-binding protein YhbY	-
I6I02_RS01350	271955..272587	+	633	WP_021143701.1	nicotinate-nucleotide adenylyltransferase	-
I6I02_RS01355	272584..273177	+	594	WP_198463659.1	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK	-
I6I02_RS01360	273181..273681	+	501	WP_198463660.1	cysteine hydrolase	-
I6I02_RS01365	273696..274046	+	351	WP_002891669.1	ribosome silencing factor	-
I6I02_RS01370	274483..275229	+	747	WP_195413993.1	class I SAM-dependent methyltransferase	-
I6I02_RS01375	275236..276327	+	1092	WP_198463661.1	nucleotidyltransferase	-
I6I02_RS01380	276469..276723	+	255	WP_060971904.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
I6I02_RS01385	276727..276981	+	255	WP_198463662.1	Txe/YoeB family addiction module toxin	Toxin
I6I02_RS01390	277690..279795	+	2106	WP_198463663.1	ATP-dependent Clp protease ATP-binding subunit	-
I6I02_RS01395	279992..280465	+	474	WP_002891962.1	IS200/IS605 family transposase	-
I6I02_RS01400	280681..281646	-	966	WP_002890057.1	IS3 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	279992..280465	473

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-75)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10111.61 Da
• Isoelectric Point: 8.8499

>T183916 WP_198463662.1 NZ_CP066093:276727-276981 [Streptococcus salivarius]
MLLAFTEDAWMDYCYWQNQDRKTLKRINKLIKDIQRDPFSGIGKPEPLKYDFQGAWSRRIDAENRLIYMIDGKSVAFLSF
KDHY

Nucleotide

• Length: 255 bp

>T183916 NZ_CP087226:c1230917-1230714 [Dickeya fangzhongdai]
ATGAAAAAAATCGACTATTTAATGCGTTTGCGTAAATGCACAACCATCGACACGCTTGAGCGTGTTATAGAAAAAAACAA
GTACGAGCTTTCCAACGATGAGCTTGAAATGTTCTATTCAGCTGCAGACCACCGCCTGGCAGAGCTGACGATGAATAAGC
TTTACGACAAAGTACCAACTGCTGTGTGGAAATACGTTCGTTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9719.00 Da
• Isoelectric Point: 4.8782

>AT183916 WP_060971904.1 NZ_CP066093:276469-276723 [Streptococcus salivarius]
MEAVVYSTFRNHLKDYMKKVNDEFEPLAVVNKNPDEDIVVVSKSEWDSIQETLRIVQNKELSDKVLRGMAQVRAGETQEH
ALKE

Nucleotide

• Length: 255 bp

>AT183916 NZ_CP087226:c1231339-1230971 [Dickeya fangzhongdai]
ATGGATGAGTACACACCTCAACATTATGATATTGCCCAACTCAGATTCTTGTGTGAAAATCTGCACGACGAAAGTATCGC
GACATTAGGTGACAGCAGTCATGGCTGGGTGAATGATCCGACCTCTGCGGTCAACCTTCAACTAAACGAACTTATCGAGC
ATATTGCGGCATTTGTTGTTACCTACAAAATAAAATACCCGCATGAAGCGGCGTTATGTGAACGGGTTGAGAAATATCTG
GACGACACTTATATTCTTTTCAGCAATTACGGTATAAATGACTCCGAGTTGCAGAAATGGAAAAAATCCAAGTCACAATT
ATTCAGAATGTTCTCAGAAAAGAGCATCTGTACGGTAGTAAAAACTTAA

Structures

Antitoxin

• AlphaFold DB: A0A2I1TMD2