Detailed information of TA system TA183883

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 900280..900538
• Replicon: chromosome
• Accession: NZ_CP066085
• Organism: Escherichia fergusonii strain FDAARGOS_1032

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: -
• Locus tag: I6H89_RS04380
• Protein ID: WP_001135723.1
• Coordinates: 900280..900432 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	900483..900538 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6H89_RS04355	896144..896854	-	711	WP_000190514.1	DUF3053 domain-containing protein	-
I6H89_RS04360	897292..898662	+	1371	WP_000184983.1	MFS transporter	-
I6H89_RS04365	898912..899202	+	291	WP_000455800.1	HTH-type transcriptional regulator	-
I6H89_RS04370	899484..899696	+	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
I6H89_RS04375	899750..900121	-	372	WP_001037804.1	membrane protein insertion efficiency factor YidD	-
I6H89_RS04380	900280..900432	-	153	WP_001135723.1	type I toxin-antitoxin system toxin HokA	Toxin
-	900483..900538	+	56	-	-	Antitoxin
I6H89_RS04385	900755..902824	-	2070	WP_001291786.1	glycine--tRNA ligase subunit beta	-
I6H89_RS04390	902834..903745	-	912	WP_001168544.1	glycine--tRNA ligase subunit alpha	-
I6H89_RS04395	903841..904140	-	300	WP_024256552.1	YsaB family lipoprotein	-
I6H89_RS04400	904312..905307	+	996	WP_015953832.1	acyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5899.14 Da
• Isoelectric Point: 6.9160

>T183883 WP_001135723.1 NZ_CP066085:c900432-900280 [Escherichia fergusonii]
MPQKYGLLSLIVICFTLLFFTWMIRDSLCELHIKQESYELAAFLACKLKE

Nucleotide

• Length: 153 bp

>T183883 NZ_CP087201:519771-520067 [Pseudomonas sp. B21-059]
ATGCACATCATCACCGCAAAACGTATCCGGCAGGCCAAGGAGCAATGGCCGCAAGTCGCGCGGGCGCTGGATACCTGGTA
CCGCAAGGCCAAAGGCGCCAGACCGGCTGATTTCGCCGACATGAAGGCCTTGTTCCCGGCGCTAGACAAGGTCGGGCGCT
TTCATGTTTTCGACATTGGCGGCAACAAACTGAGGCTGATCGCAATCGTGCGCTATGGGGGGCAGCGCCTCTATATCAGG
CATGTGCTGGATCACGGCGAATACGACAAGGGGCTGTGGAAGGAGGAATCACAATGA

Antitoxin

Nucleotide

• Length: 56 bp

>AT183883 NZ_CP066085:900483-900538 [Escherichia fergusonii]
GTTGAAGCATAGAGGCAGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Antitoxin