Detailed information of TA system TA183877

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-agrB/Ldr(toxin)
• Location: 869485..869704
• Replicon: chromosome
• Accession: NZ_CP066085
• Organism: Escherichia fergusonii strain FDAARGOS_1032

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: I6H89_RS04225
• Protein ID: WP_001295224.1
• Coordinates: 869485..869592 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	agrB
Locus tag	-
Coordinates	869650..869704 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6H89_RS04200	864721..865488	-	768	WP_000279501.1	cellulose biosynthesis protein BcsQ	-
I6H89_RS04205	865500..865688	-	189	WP_001063310.1	YhjR family protein	-
I6H89_RS04210	865975..867534	+	1560	WP_001070267.1	cellulose biosynthesis protein BcsE	-
I6H89_RS04215	867531..867722	+	192	WP_000981122.1	cellulose biosynthesis protein BcsF	-
I6H89_RS04220	867719..869398	+	1680	WP_000192007.1	cellulose biosynthesis protein BcsG	-
I6H89_RS04225	869485..869592	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	869650..869704	+	55	NuclAT_19	-	Antitoxin
-	869650..869704	+	55	NuclAT_19	-	Antitoxin
-	869650..869704	+	55	NuclAT_19	-	Antitoxin
-	869650..869704	+	55	NuclAT_19	-	Antitoxin
-	869650..869704	+	55	NuclAT_21	-	Antitoxin
-	869650..869704	+	55	NuclAT_21	-	Antitoxin
-	869650..869704	+	55	NuclAT_21	-	Antitoxin
-	869650..869704	+	55	NuclAT_21	-	Antitoxin
-	869650..869704	+	55	NuclAT_23	-	Antitoxin
-	869650..869704	+	55	NuclAT_23	-	Antitoxin
-	869650..869704	+	55	NuclAT_23	-	Antitoxin
-	869650..869704	+	55	NuclAT_23	-	Antitoxin
-	869650..869704	+	55	NuclAT_25	-	Antitoxin
-	869650..869704	+	55	NuclAT_25	-	Antitoxin
-	869650..869704	+	55	NuclAT_25	-	Antitoxin
-	869650..869704	+	55	NuclAT_25	-	Antitoxin
-	869650..869706	+	57	NuclAT_12	-	-
-	869650..869706	+	57	NuclAT_12	-	-
-	869650..869706	+	57	NuclAT_12	-	-
-	869650..869706	+	57	NuclAT_12	-	-
-	869650..869706	+	57	NuclAT_14	-	-
-	869650..869706	+	57	NuclAT_14	-	-
-	869650..869706	+	57	NuclAT_14	-	-
-	869650..869706	+	57	NuclAT_14	-	-
I6H89_RS04230	869967..870074	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
I6H89_RS04235	870449..870556	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
I6H89_RS04240	870932..871039	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
-	871088..871151	+	64	NuclAT_18	-	-
-	871088..871151	+	64	NuclAT_18	-	-
-	871088..871151	+	64	NuclAT_18	-	-
-	871088..871151	+	64	NuclAT_18	-	-
-	871088..871151	+	64	NuclAT_20	-	-
-	871088..871151	+	64	NuclAT_20	-	-
-	871088..871151	+	64	NuclAT_20	-	-
-	871088..871151	+	64	NuclAT_20	-	-
-	871088..871151	+	64	NuclAT_22	-	-
-	871088..871151	+	64	NuclAT_22	-	-
-	871088..871151	+	64	NuclAT_22	-	-
-	871088..871151	+	64	NuclAT_22	-	-
-	871088..871151	+	64	NuclAT_24	-	-
-	871088..871151	+	64	NuclAT_24	-	-
-	871088..871151	+	64	NuclAT_24	-	-
-	871088..871151	+	64	NuclAT_24	-	-
-	871088..871153	+	66	NuclAT_11	-	-
-	871088..871153	+	66	NuclAT_11	-	-
-	871088..871153	+	66	NuclAT_11	-	-
-	871088..871153	+	66	NuclAT_11	-	-
-	871088..871153	+	66	NuclAT_13	-	-
-	871088..871153	+	66	NuclAT_13	-	-
-	871088..871153	+	66	NuclAT_13	-	-
-	871088..871153	+	66	NuclAT_13	-	-
I6H89_RS04245	871475..872671	+	1197	WP_001016304.1	methionine gamma-lyase	-
I6H89_RS04250	872921..874219	+	1299	WP_001152710.1	amino acid permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T183877 WP_001295224.1 NZ_CP066085:c869592-869485 [Escherichia fergusonii]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T183877 NZ_CP087199:c1483082-1482213 [Pseudomonas sp. B21-009]
ATGTTGCACGCCACCGACCACTCGCTCGCCGGCCTTGCAGCCCAGTTGCAGCAGCGCTTCCCCCAGCGCCTGGTGCAACT
GGCAAGCGGCGCCCAGGCGATCCGCGAAGCCGGGCAAGGGCCGGCCATCGTGCTGTTGCATGGCATTGGCTCGGGCGCCG
CGTCCTGGCTGCAGGTGGCGCTGCAACTGAGCCAGCAGGCCCGGGTGATTGCCTGGGATGCACCGGGCTACGGCGACTCC
AGCCCGCTGGCCAACCCTGCGCCGCAGGCGGTGGACTATGCCCGGCGCCTGCGGCATTTGCTCGATGCGCTGCAGATTGC
CGACTGCCTGCTGGTCGGCCATTCCCTCGGTGCCCTCAGCGCCGCGGCCCTGGCCCAGCAGCAGCCGCAACGGGTGCGGC
GCCTGGTGCTGATCAGCCCGGCTCGCGGCTATGGCGACCCGGCCCGTGCCGAGCAGGCGCAACAAGTACGCCGCCAGCGC
CTGCACAACCTTGAGCAACTGGGCATCGCCCAGATGGCCCACCAGCGCAGCGCGCACATGCTCTCGCCAGCGGCCAGCAG
CGAGGCCCGCGCCTGGGTGCAATGGAACATGGCGCGGCTGCTGCCCCAGGGCTATCGCCAGGCCATCGAGTTGCTGTGTG
GCGATGACCTGCTGCGCTACGCCGCCCTGGCCGTGCCATGCGAAGTGCATTGCGGCGCCGCTGACAGCATCACCCGCCCC
GAGGACTGCCAGGCCCTGGCCAAGGCCCTGGGGGCAGCGTTCGCGTTGATTGCCGAGGCCGGCCACGCCAGCCCGATCGA
ACAACCCGAGGCCGTGGCAACGCTGCTTGCCCGGGCCCTCGAAGAATCCCTGACAGGTACTGCGCTATGA

Antitoxin

Nucleotide

• Length: 55 bp

>AT183877 NZ_CP066085:869650-869704 [Escherichia fergusonii]
CAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin