Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3611022..3611775 Replicon chromosome
Accession NZ_CP066075
Organism Paraburkholderia ginsengisoli strain FDAARGOS_1049

Toxin (Protein)


Gene name graT Uniprot ID A0A7T4T8D6
Locus tag I6I06_RS16200 Protein ID WP_042321712.1
Coordinates 3611494..3611775 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag I6I06_RS16195 Protein ID WP_042321709.1
Coordinates 3611022..3611477 (-) Length 152 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I06_RS16175 3607910..3608965 + 1056 WP_042321703.1 XRE family transcriptional regulator -
I6I06_RS16180 3608965..3609453 + 489 WP_042321705.1 DUF3368 domain-containing protein -
I6I06_RS16190 3609884..3610900 - 1017 WP_042321707.1 class 1 fructose-bisphosphatase -
I6I06_RS16195 3611022..3611477 - 456 WP_042321709.1 HigA family addiction module antidote protein Antitoxin
I6I06_RS16200 3611494..3611775 - 282 WP_042321712.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6I06_RS16205 3611976..3614672 - 2697 WP_042321714.1 aminopeptidase N -
I6I06_RS16210 3614902..3615600 + 699 WP_042321717.1 DUF4136 domain-containing protein -
I6I06_RS16215 3615714..3616286 - 573 WP_042321719.1 TMEM165/GDT1 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-82)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10521.14 Da        Isoelectric Point: 9.2089

>T183867 WP_042321712.1 NZ_CP066075:c3611775-3611494 [Paraburkholderia ginsengisoli]
MITTFGDKATARIFQGKFVHSLPLHIQALARRKLLMIDAADSIANLHAPPGNRLEALQGQRSGQWSIRINAQWRICFHFV
GEEALNVEIVDYH

Download         Length: 282 bp

>T183867 NZ_CP087197:c1512762-1511893 [Pseudomonas sp. B21-012]
ATGTTGCACGCCACCGACCACTCGCTCGCCGGCCTTGCGGCCCAGTTGCAGCAGCGCTTCCCCCAGCGCCTGGTGCAACT
GGCAAGCGGCGCCCAGGCGATCCGCGAAGCCGGGCACGGGCCGGCCATCGTGCTGTTGCATGGCATTGGCTCGGGCGCCG
CGTCCTGGCTGCAGGTGGCGCTGCAACTGAGCCAGCACGCCCGGGTGATTGCCTGGGATGCACCGGGCTACGGCGACTCC
AGCCCGCTGGCCAACCCTGCGCCGCAGGCGGTGGACTATGCCCGGCGCCTGCGGCATTTGCTCGATGCGCTGCAGATTGA
CGACTGCCTGCTGGTCGGCCATTCCCTCGGTGCCCTCAGCGCTGCAGCCCTGACCCAGCAGCAGCCGCAACGGGTGCGGC
GCCTGGTGCTGATCAGCCCGGCTCGCGGCTATGGCGACCCGGCCCGTGCCGAGCAGGCGCAACAGGTACGCAGCCAGCGC
CTGCACAGCCTCGAACAACTGGGCATCGCCCAGATGGCCAACCAGCGCAGCGCACACATGCTCTCGCCAGCGGCCAGCAG
CGAAGCCCGCGCCTGGGTGCAATGGAACATGGCGCGGCTGCTGCCCCAGGGCTATCGCCAGGCCATCGAGTTGCTGTGTG
GCGATGACCTGCTGCGCTACGCCGCCCTGGCCGTGCCGTACGAAGTGCATTGCGGCGCCGCTGACAGCATCACCCGCCCC
GAGGACTGCCAGGCCCTGGCCAAGGCCCTGGGGGCAGCGTTCGCGTTGATTGCCGAGGCCGGCCACGCCAGCCCGATCGA
ACAACCCGAGGCCGTGGCAACGCTGCTTGCCCGGGCCCTCGAAGAATCCCTGACAGGTACTGCGCTATGA

Antitoxin


Download         Length: 152 a.a.        Molecular weight: 16357.79 Da        Isoelectric Point: 10.0363

>AT183867 WP_042321709.1 NZ_CP066075:c3611477-3611022 [Paraburkholderia ginsengisoli]
MVIKRSSLGSIDFSDIDTGDNIPEIHPGEILRSEFLEPLGMSVNALALALRVPAPRINDVVRGKRAISADTALRLERYFG
ASAPFWLNLQIAYDLRVATAAAGEQIEREIEPMPKSDRPKMPKVSAEHTRAAALAVSVSGSHTAGKARRKA

Download         Length: 456 bp

>AT183867 NZ_CP087197:c1511896-1511069 [Pseudomonas sp. B21-012]
ATGAATGATTCGGATCTGTTGAAAGACAACCAGGACAAGTACATCGTCCCCGGCCTTGAGCGCGGCCTGTTGCTGCTCTG
TGAATTCAGCCGGCAAAACCGCACCCTCACCGCGCCGGAACTGGCGCGGCGCCTGGAGCTGCCGCGCTCGACCATCTTCC
GCCTGTTGACCACCCTGGAAACCATGGGCTTCGTCACCCGCAGCGGCAACGAGTACCGCCTGGGCATGTCGGTACTGCGC
CTGGGCTTCGAGTACCTGGCATCGCTTGAACTGACCGAGCTCGGTCAGCCGCTGCTGGCGCGGCTGTGCGATCACCTTAA
TTACCCGAGCAACCTGGTGGTGCGTGACGGTCGCTCGATCGTCTACGTGGCCAAGGTTTCGCCGCCGTCGGTGTTCTCCA
GCGCGGTCAACGTCGGCACCCGCCTGCCGGCCCACGCCACGGTGCTGGGGCGCATCCTCCTTGAAGACCTGAGCCTGGCC
GAGCTACGTGAGCTGTACCCGGAGGAGCACCTGGAACAGCACTCGCCGTGCACACCGAAAACCGTACTGGAGCTGTTCGA
CCTGGTGCAGAGCGACCGTCAGCGCGGCTATGTCAGCGGCGAAGGTTTTTTCGAATCATCGATCTCGACCATCGCTGCGC
CGGTGCGCGATCACAGTGGCCGGGTGGTTGCCGCCATGGGCGTGACCATCCCTACCGTGCAGGTTGCGCACATCAATTTC
GACGGCCTGCTTGGCCATGTGCGGGGCAGCGCCGACGAGCTGTCGCGCCTGCTCAACTACACGCCAAACGCTGGCTCCGG
CCGCGTCACCGCGCTGATGAGGGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T4T8D6

Antitoxin

Source ID Structure

References