Detailed information of TA system TA183865

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 206044..206557
• Replicon: chromosome
• Accession: NZ_CP066073
• Organism: Streptococcus dysgalactiae strain FDAARGOS_1016

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: I6H73_RS01070
• Protein ID: WP_003053779.1
• Coordinates: 206044..206298 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: I6H73_RS01075
• Protein ID: WP_003053797.1
• Coordinates: 206291..206557 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6H73_RS01040	202286..202696	-	411	WP_003053802.1	conjugal transfer protein	-
I6H73_RS01045	202699..202923	-	225	WP_003053785.1	hypothetical protein	-
I6H73_RS01050	202927..203937	-	1011	WP_003053776.1	conjugal transfer protein	-
I6H73_RS01055	203949..204485	-	537	WP_003053800.1	hypothetical protein	-
I6H73_RS01060	204512..204742	-	231	WP_003053793.1	hypothetical protein	-
I6H73_RS01065	204762..205988	-	1227	WP_003053775.1	replication initiation factor domain-containing protein	-
I6H73_RS01070	206044..206298	-	255	WP_003053779.1	Txe/YoeB family addiction module toxin	Toxin
I6H73_RS01075	206291..206557	-	267	WP_003053797.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
I6H73_RS01080	206822..208509	-	1688	Protein_213	cell division protein FtsK	-
I6H73_RS01085	208526..208987	-	462	WP_003056467.1	hypothetical protein	-
I6H73_RS01090	209006..209302	-	297	WP_003056470.1	hypothetical protein	-
I6H73_RS01095	209342..209587	-	246	WP_003056472.1	hypothetical protein	-
I6H73_RS01100	210160..210501	+	342	WP_111711548.1	helix-turn-helix domain-containing protein	-
I6H73_RS01105	210705..211010	+	306	WP_003053653.1	hypothetical protein	-
I6H73_RS01110	211045..211404	-	360	WP_003053656.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	177569..220610	43041

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (2-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10501.83 Da
• Isoelectric Point: 8.4060

>T183865 WP_003053779.1 NZ_CP066073:c206298-206044 [Streptococcus dysgalactiae]
MFNFTEEAWEDYTSWQREDKKILKRINRLIEDIKRHPFEGIGKPEPLKYRYSGAWSRRITDEHRLVYTVEQNDIYFLSFR
DHYK

Nucleotide

• Length: 255 bp

>T183865 NZ_CP087197:974441-974734 [Pseudomonas sp. B21-012]
TTGAAATATAGTGTTTTGCAGACACCCAGATTTACCTCGTGGTTAGTTTCTGTGCGCGACCTCCGTGCAAGGTTGGCCAT
CGCACGGCGAATAGAGCGTGCAACGGCAGGAAACCTGGGGGATGTGAAGTCCGTCGGTGGCCAGGTTTCCGAGATGCGCA
TCGATGTGGGTGCGGGTTATCGGGTGTACTTCACGGTTCGGGACGGGATGGTCATTGTTTTGTTGGCAGGGGGTGACAAG
TCATCTCAATCTGCTGATATCCAACTAGCCAGGAAGTTGGCCAAGGAAATCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10402.81 Da
• Isoelectric Point: 4.5216

>AT183865 WP_003053797.1 NZ_CP066073:c206557-206291 [Streptococcus dysgalactiae]
MEAVVYSNFRNNLKDYMKKVNDEYEPLMVVNKNPEENIVVLSKDNWDSIQETIRIMNNEYLSDKVLSGLEQVKQKKVTQH
QLLEVEDV

Nucleotide

• Length: 267 bp

>AT183865 NZ_CP087197:974736-975035 [Pseudomonas sp. B21-012]
ATGAGCTTGTCACTCACCACCTTTGATATGGCAGCCTTGCTCGATAGTGATGAAGCTATCAGCGAGTACCTTTCCCAAGT
TCTGGCGGATGGAGATCATGACGAACTGATACGTGCCCTTGGCCATATCGCCAAGGCGCGCGGCATGAGTCAGATTGCAA
GCGCAAGTGGGTTGGGGCGCGAGAGTCTGTACAAGGCATTAACCCCGGGTGCGAAGCCTCGTTTTGATACTGTACTGAAG
GTCATTCGAGCGTTAGGGATTGATCTTCTGGCTCATCCTCACACTTCCTCGAGGCTCTGA