Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-couple_hipB
Location 1036079..1036730 Replicon chromosome
Accession NZ_CP066069
Organism Streptococcus dysgalactiae strain FDAARGOS_1017

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag I6H74_RS05140 Protein ID WP_046177189.1
Coordinates 1036079..1036444 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag I6H74_RS05145 Protein ID WP_027971722.1
Coordinates 1036434..1036730 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6H74_RS05095 1031124..1032008 + 885 WP_053042318.1 ATP-binding protein -
I6H74_RS05100 1032258..1032440 + 183 WP_000273649.1 hypothetical protein -
I6H74_RS05105 1032538..1032726 + 189 Protein_941 hypothetical protein -
I6H74_RS05115 1033986..1034378 + 393 Protein_943 hypothetical protein -
I6H74_RS05120 1034375..1034662 + 288 WP_046177192.1 hypothetical protein -
I6H74_RS05125 1034701..1035129 + 429 WP_053042316.1 hypothetical protein -
I6H74_RS05130 1035122..1035448 + 327 WP_046177191.1 hypothetical protein -
I6H74_RS05135 1035466..1035861 + 396 WP_046177190.1 hypothetical protein -
I6H74_RS05140 1036079..1036444 + 366 WP_046177189.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6H74_RS05145 1036434..1036730 + 297 WP_027971722.1 helix-turn-helix transcriptional regulator Antitoxin
I6H74_RS05150 1036752..1037957 + 1206 WP_046177188.1 hypothetical protein -
I6H74_RS05155 1037964..1038131 + 168 WP_165626014.1 hypothetical protein -
I6H74_RS05160 1039007..1039168 + 162 WP_012766767.1 TOMM family cytolysin streptolysin S -
I6H74_RS05165 1039387..1040337 + 951 WP_003061458.1 SagB family peptide dehydrogenase -
I6H74_RS05170 1040334..1041398 + 1065 WP_046177187.1 streptolysin associated protein SagC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(35-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-88)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 14390.55 Da        Isoelectric Point: 9.7920

>T183858 WP_046177189.1 NZ_CP066069:1036079-1036444 [Streptococcus dysgalactiae]
VHNIYFYKDKNGNEPVLDYMRELASKKGKDSRIKLNKINDYIELLSQHGTRAGEPYIKHLDAEIWELRPLRDRILFVAWI
DGSFVLLHHFMKKTQKTPKREIDQAKRELADLKERGLDNEK

Download         Length: 366 bp

>T183858 NZ_CP087194:4797895-4798470 [Pseudomonas sp. B21-017]
GTGAGGCACTCCCCTTTTACCGCTGTATATGACGCATGTGTTTTGTACCCCGCCCCCTTGAGAGATTTTTTGATGTGGCT
CGCGCTCTCCGGGCGTTTCAGGGCGCGATGGTCACTGGAGATACATAACGAATGGAAGCGCAATCTACTGAAGAACCGCC
CGGACCTGACAACAGAGCAGTTGGATCGCACGTCCGACTTGATGGATCAGGCCATACCTGATGCTTGCGTCTACGGTTAC
GAAAGGCTGATCGAAGGGCTAACACTGCCTGACGTCGATGACCGACATGTTCTGGCTGCCGCTATACGCTGCAATGCCAG
TGTCATTGTGACCTTTAATCAGAAAGATTTTCCTGACGAAACACTGGGACCTTTTGGCATCGAGGCCCAGCATCCTGACG
AGTTCGTCGATAACCTCTTCGATCTGGACCCGGCAGCAGTTGTTGCGGCAGCACAACGACAACGCAAACAGCTAAAGACG
CCGCCGATGGATGTCAGCACTTATCTCGAACTGCTGTTACGCCTGGGCCTGACTCGGTCGAGCAAGGCGTTGACCCACTA
TCAGGCAATTCTTTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10758.43 Da        Isoelectric Point: 4.8898

>AT183858 WP_027971722.1 NZ_CP066069:1036434-1036730 [Streptococcus dysgalactiae]
MKNNAIGSNWKDVRAELFSKEEILESDMRVAIMSELIEARNEKGISQKKLEEMSGVSQPVIARMETGKTSPQLDTVLKVL
ASLGKTLAVVPIEGEQVS

Download         Length: 297 bp

>AT183858 NZ_CP087194:4797431-4797898 [Pseudomonas sp. B21-017]
ATGTCACCAGTTATCCATCCCCCCCTTAACCTGCCCATGGAGCGTGAGGTCCAGGCCGCTATCGAAGGTCAGCGCGCCTT
GGCTGCCTACCTCGCCACCCAATTCGAAACTCAGCATATCCAGATTTTCGATGAGCAGAATGAAGCACACAGCGTCGAAC
TTCCCACCTCAGCGCTTCGGTTGCTTGTCGACATCCTGGCAGAGCTCGCTGCAGGCAACGCCGTCAAAGTGGTCCCGGTA
CACGCTGAACTGACCACCCAGGAAGCGGCGGACTTGCTCAATGTCTCACGCCCGCACCTGATCAAACTGCTGGAGTCCGG
TGAGTTGTCCTACCACAAAACCGGCAAGCACCGACGTGTGCGCTTTACCGATTTGATGGACTATAAAACCCAGCGCGACA
TAGCCAGCGAGCAAGCAATGACGCTTCTCGCCGAGCAGGCACAAGCGTTAAGGACAGGATACGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References