Detailed information of TA system TA183840

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 1525141..1525683
• Replicon: chromosome
• Accession: NZ_CP066057
• Organism: Moraxella nonliquefaciens strain FDAARGOS_1006

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: I6H63_RS07500
• Protein ID: WP_145916045.1
• Coordinates: 1525462..1525683 (-)
• Length: 74 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A1B8QSB1
• Locus tag: I6H63_RS07495
• Protein ID: WP_067007252.1
• Coordinates: 1525141..1525440 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6H63_RS07480	1521838..1523157	-	1320	WP_067007262.1	DUF262 domain-containing protein	-
I6H63_RS07485	1523291..1524058	-	768	WP_067007258.1	hypothetical protein	-
I6H63_RS07490	1524163..1525104	-	942	WP_067007255.1	WYL domain-containing protein	-
I6H63_RS07495	1525141..1525440	-	300	WP_067007252.1	helix-turn-helix transcriptional regulator	Antitoxin
I6H63_RS07500	1525462..1525683	-	222	WP_145916045.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I6H63_RS07505	1526004..1527395	-	1392	WP_067007249.1	class II fumarate hydratase	-
I6H63_RS07510	1527507..1528070	+	564	WP_067007246.1	5-formyltetrahydrofolate cyclo-ligase	-
I6H63_RS07515	1528167..1529510	-	1344	WP_066893213.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (4-66)

Antitoxin

• HigA2-like, helix-turn-helix domain (10-88)

Sequences

Toxin

Protein

• Length: 74 a.a.
• Molecular weight: 8352.58 Da
• Isoelectric Point: 6.1700

>T183840 WP_145916045.1 NZ_CP066057:c1525683-1525462 [Moraxella nonliquefaciens]
MLCPYSDTLYDSKFNNMKELRIQIGGDPYRAFYTFDPIRQAIVLCAGNKVGNEKQFYKQMIPLADEFTSAAFG

Nucleotide

• Length: 222 bp

>T183840 NZ_CP087189:4493208-4493558 [Pseudomonas protegens]
ATGAATGCTCTGTTTATTGAACTACCGGCATTTGCGCGATACCGAAAAGGCTTCCTTGACGACGAGTTGTTCTGCGAACT
GCAGATCGAGTTGCTGCGTCACCCGCACGCGGGTGTTCTGATTCAGGGCACTGGCGGCTTGCGCAAGATGCGTTTCGTCG
ATGAGCGACGCAACAAGGGCAGGCGTGGCGGGCTGAGGGTGATTTATTACTGGTGGTCCGGAGGAGCACAGTTCTGGCTC
TTCACCCTGTTCGACAAGGAGCAGATGGACGACCTGCTACCGCAGCAGCGACAACAGCTCAAACAACTGCTGGAACGTGA
AATCGAGGCCAGACGACATGACCAAACGTGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11181.09 Da
• Isoelectric Point: 6.9808

>AT183840 WP_067007252.1 NZ_CP066057:c1525440-1525141 [Moraxella nonliquefaciens]
MANLNDMLAKSPKERLARVQKMADEMILDYKLYQLREELELSQKQLAEAMGITQPTLSAIENRGAEIKLSTLKCYVETMG
GKLRIDVELPTGKHVGFNI

Nucleotide

• Length: 300 bp

>AT183840 NZ_CP087189:4493545-4493862 [Pseudomonas protegens]
ATGACCAAACGTGACATCTTTTCCGAACTGGTTGAAGGCATCGACGCCCTCACCCAGGAACGCCAGGGCAAGATCACCCT
GCGCAGCCATAAAGTGAAACTCGACAAGCTGCCCCCCATCACCGCCGCCGAGGTGATGAACATCCGCCAGCAACTCAACC
TCTCGCGCTCGGTGTTCGCCATGTACCTGCGCACCAACACCCGCACCCTGGAGAACTGGGAACAGGGCCGCGCCATACCC
AACGCCCAGGCCACGACCTTGATACGCCTGGTGGAGCGCTACCCCGATACAGTGGAGCGCCTCGCTTCGCTGGCCTGA

Structures

Antitoxin

• AlphaFold DB: A0A1B8QSB1