Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1488192..1488785 Replicon chromosome
Accession NZ_CP066057
Organism Moraxella nonliquefaciens strain FDAARGOS_1006

Toxin (Protein)


Gene name higB Uniprot ID A0A1B8QSE2
Locus tag I6H63_RS07335 Protein ID WP_067007315.1
Coordinates 1488507..1488785 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1B8QSE0
Locus tag I6H63_RS07330 Protein ID WP_067007318.1
Coordinates 1488192..1488497 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6H63_RS07290 1483810..1484214 - 405 WP_067007336.1 type II toxin-antitoxin system HicB family antitoxin -
I6H63_RS07295 1484248..1484440 - 193 Protein_1382 type II toxin-antitoxin system HicA family toxin -
I6H63_RS07300 1484734..1484910 + 177 WP_158512463.1 helix-turn-helix domain-containing protein -
I6H63_RS07305 1485342..1485734 + 393 WP_067007331.1 hypothetical protein -
I6H63_RS07310 1485788..1486495 + 708 WP_067007329.1 phage minor tail protein L -
I6H63_RS07315 1486505..1487059 + 555 WP_067007326.1 hypothetical protein -
I6H63_RS07320 1487007..1487435 + 429 WP_067007324.1 hypothetical protein -
I6H63_RS07325 1487432..1488220 + 789 WP_067007321.1 C40 family peptidase -
I6H63_RS07330 1488192..1488497 - 306 WP_067007318.1 HigA family addiction module antidote protein Antitoxin
I6H63_RS07335 1488507..1488785 - 279 WP_067007315.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6H63_RS07340 1488860..1489444 + 585 WP_067007313.1 tail assembly protein -
I6H63_RS07345 1489441..1489716 - 276 WP_067007310.1 BrnA antitoxin family protein -
I6H63_RS07350 1489721..1489993 - 273 WP_067007307.1 BrnT family toxin -
I6H63_RS07355 1490080..1490550 + 471 WP_067007304.1 hypothetical protein -
I6H63_RS07360 1490748..1493720 - 2973 WP_145916046.1 bifunctional [glutamate--ammonia ligase]-adenylyl-L-tyrosine phosphorylase/[glutamate--ammonia-ligase] adenylyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1475040..1494527 19487


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10642.08 Da        Isoelectric Point: 5.8378

>T183839 WP_067007315.1 NZ_CP066057:c1488785-1488507 [Moraxella nonliquefaciens]
MIKSFKCKDTKTLFETGESRVFGNFLSVATRKLTYLDNAVTLDALRSPPANRLEKLVGDREGQYSIRINDQFRICFVWSE
DGVYDVEIVDYH

Download         Length: 279 bp

>T183839 NZ_CP087189:3057520-3058119 [Pseudomonas protegens]
ATGAACAGTGAACTTCTCAGTGGCCGCCTCGACTTTCTCCGTGAAGCGGAAAAACTCAAGGACGTGCTGCGCAGCGCCCA
CACCTCCAGCGGCCGCCAGGAAAGTACGGCCGAGCACAGCTGGCGCCTATGCCTGATGGCGCTGCTGTTCGAAGACCAAC
TGGGGGACCTGGACCTGCTGCGGGTGCTGAAACTGTGCATCGTCCACGACCTGGGGGAGGCCATTCATGGCGATATCCCG
GCGGTGCAGCAGGCGGCCCACCCGGACAAGAGCCAGCAGGAGCGCGCGGACCTGCAACTGCTGGCCCGAGCCCTGGACGC
CCCGGCCCGCGAGCACCTGCTGGAGCTGTGGGACGAATACGAAGGCGCCGCCAGCGCCGAGGCGCAGACGGTCAAGGCCC
TGGACAAGCTGGAAACCCTGCTGCAACACACCCAGGGCCAGAACCCGGCGGGTTTCGACTACCGCTTCAACCTCGGCTAC
GGCCGCCGCTACACCGACGCCAGCCCACTGTTCCAGGCCCTGCGCCAGCAGATCGATGCCGACACCCAGCGCCGCCTGGA
CGCCCAGGCTCAGGCCGCTGTTCACCATCGGCTGCGCTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11282.88 Da        Isoelectric Point: 5.6925

>AT183839 WP_067007318.1 NZ_CP066057:c1488497-1488192 [Moraxella nonliquefaciens]
MFKNGMRPVHAGEILREDYLKPLGMSANALAKALGVTPARINDIVLERRGITADTALRLARYFGGDAQTWLNLQSTYELR
LAENELGDSLEHISPYEVCYT

Download         Length: 306 bp

>AT183839 NZ_CP087189:3056844-3057401 [Pseudomonas protegens]
ATGTCCGCAGCCCCGTTCACCTCACCCCATCTGGGCCTGGCCCTCAGGCGCTGGCGCCTGTTGCACCGGGTCAAGCAGCA
GCACGCCGCCGAGTTGTTCGGTGTGGCGCAGTCGAGCATTTCCCGTTGGGAAAACGGCCGGCAAGCCATGGAGCCGGCAG
AGCGTGCGCGCTTGGAGCAACTGCTGGCGGCCAACCTCAGCGCCGCCGCCGATCAGGCCCTGGCGCGGCTGGTGAACGAC
AGCCCGCGCGCCGTGCACCTGGTGTGCGACCTGACCCACCGCCTGCTGGCCTGTTCCGCCACCCGCGCCGGGCAGTTCGG
CGTGCCCTTGAGTGAGCTGCTGGGGCACTCCCTGTGGGGCTTCTGCACCGAGGAAATCGTGCGCAAGGAAGCCGCCCTGG
ATGACCTGGGCTGGCGCGAAGTGCTGGCGCCGCCGTCCCTGGAGTTCTTCAGCGGCCACAACGATTCGGCCATCGTGCCC
ATCGCCCCCAGCCAGTGCCGCTGGACCCGCCTCAACCTCTCTGACGGCAACGCCGTGCGCCTGGTGGAAACCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B8QSE2

Antitoxin

Source ID Structure
AlphaFold DB A0A1B8QSE0

References