Detailed information of TA system TA183837

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-couple_hipB
• Location: 1841921..1842572
• Replicon: chromosome
• Accession: NZ_CP066055
• Organism: Streptococcus constellatus strain FDAARGOS_1015

Toxin (Protein)

• Gene name: higB
• Uniprot ID: F9P6Y3
• Locus tag: I6H72_RS09355
• Protein ID: WP_006268450.1
• Coordinates: 1841921..1842286 (+)
• Length: 122 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: I6H72_RS09360
• Protein ID: WP_020997975.1
• Coordinates: 1842276..1842572 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6H72_RS09320	1837182..1837514	+	333	WP_198457928.1	hypothetical protein	-
I6H72_RS09325	1837655..1838962	+	1308	WP_003030075.1	ISLre2 family transposase	-
I6H72_RS09330	1839525..1840139	+	615	WP_134970310.1	hypothetical protein	-
I6H72_RS09335	1840158..1840640	+	483	WP_198457929.1	hypothetical protein	-
I6H72_RS09340	1840621..1841031	+	411	WP_006268286.1	hypothetical protein	-
I6H72_RS09345	1841270..1841500	+	231	WP_022525741.1	hypothetical protein	-
I6H72_RS09350	1841580..1841855	+	276	WP_006268376.1	terminase small subunit	-
I6H72_RS09355	1841921..1842286	+	366	WP_006268450.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I6H72_RS09360	1842276..1842572	+	297	WP_020997975.1	helix-turn-helix transcriptional regulator	Antitoxin
I6H72_RS09365	1842594..1843799	+	1206	WP_020997974.1	hypothetical protein	-
I6H72_RS09370	1843806..1843973	+	168	WP_006268192.1	hypothetical protein	-
I6H72_RS09375	1844337..1846397	+	2061	WP_198457930.1	penicillin-binding protein PBP2B	-
I6H72_RS09380	1846408..1847004	+	597	WP_198457931.1	recombination mediator RecR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (35-109)

Antitoxin

• Cro/C1-type helix-turn-helix domain (33-88)

Sequences

Toxin

Protein

• Length: 122 a.a.
• Molecular weight: 14448.63 Da
• Isoelectric Point: 9.7920

>T183837 WP_006268450.1 NZ_CP066055:1841921-1842286 [Streptococcus constellatus]
VHNIYFYKDKNGNEPILDYMRELASKKGKDSRIKLNKINDYIELLSQHGTRTGEPYIKHLDAEIWELRPLRDRILFVAWI
DGSFVLLHHFMKKTQKTPKREIEQAKRELADLKERGLDNEK

Nucleotide

• Length: 366 bp

>T183837 NZ_CP087189:c2535477-2535295 [Pseudomonas protegens]
GTGCAAAGCAGACAGTTGATCAAGGAGCTTGAAGCCGCAGGCTGGGTGCTGGAGCGAGTCACTGGCAGCCATCATCTGTT
CAAGCACCCTTACAGGCCCAACACCGTTCCGGTGCCTCACCCGAAGAAGGATCTGCCACGGGGCACGGTCAGGGCCATCA
GAAAACTGGCTGAACTGATCTAG

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 10755.42 Da
• Isoelectric Point: 4.8898

>AT183837 WP_020997975.1 NZ_CP066055:1842276-1842572 [Streptococcus constellatus]
MKNSAIGSNWKDVRAELFSKEEILESDMRVAIMSELIEARNERGISQKKLEELSGVSQPVIARMETGKTSPQLDTVLKVL
ASLGKTLAVVPLEGEQIS

Nucleotide

• Length: 297 bp

>AT183837 NZ_CP087189:c2535259-2534858 [Pseudomonas protegens]
GTGCAATATCCCATCTGCATCGAGTGGGGCGACGAACACACCGCCACCGGCATCCAGATTCCTGATATTCCCGGTGCTGT
CACCGCCGGCGACAGCTTCGAGAGCGCCTATAGCGCCGCCATCGAGATTGCCCACGTCATGCTCGAAGAGCTGGCCCGCG
CGGGGAACGCCATTCCCCTGCCCTCACCCACCCGCAATCACCGCGCCAACCCCGATTTCGAGGGCATGGGCTGGGGCATG
CTGGATATCGATATCGCGCCTTATCTGGGCAAGACCGAGAAGGTCAACGTGACCCTGCCGGGTTATGTGATCCAGCAGAT
CGACCGCTTTGTCCGCGAGCACAACATCAAGAGCCGGTCGTCTTTCCTGGCCGATGCGGCGATGGAAAAGCTCGGACGCT
GA

Structures

Toxin

• AlphaFold DB: F9P6Y3