Detailed information of TA system TA183826

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 667799..668311
• Replicon: chromosome
• Accession: NZ_CP066041
• Organism: Streptococcus oralis strain FDAARGOS_1075

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: D4FRF2
• Locus tag: I6I32_RS03265
• Protein ID: WP_000924723.1
• Coordinates: 667799..668053 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: I6I32_RS03270
• Protein ID: WP_004181012.1
• Coordinates: 668057..668311 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6I32_RS03250	664882..665196	-	315	WP_002874282.1	DNA-directed RNA polymerase subunit omega	-
I6I32_RS03255	665221..665847	-	627	WP_000775041.1	guanylate kinase	-
I6I32_RS03260	665982..667595	-	1614	WP_000404960.1	ribonuclease Y	-
I6I32_RS03265	667799..668053	-	255	WP_000924723.1	Txe/YoeB family addiction module toxin	Toxin
I6I32_RS03270	668057..668311	-	255	WP_004181012.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
I6I32_RS03275	668444..669541	-	1098	WP_198464917.1	nucleotidyltransferase	-
I6I32_RS03280	669551..670297	-	747	WP_081102369.1	class I SAM-dependent methyltransferase	-
I6I32_RS03285	670614..670967	-	354	WP_001003013.1	ribosome silencing factor	-
I6I32_RS03290	670968..671561	-	594	WP_198464918.1	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK	-
I6I32_RS03295	671561..672190	-	630	WP_000963715.1	nicotinate-nucleotide adenylyltransferase	-
I6I32_RS03300	672243..672554	-	312	WP_049501124.1	ribosome assembly RNA-binding protein YhbY	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-75)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10113.58 Da
• Isoelectric Point: 7.9716

>T183826 WP_000924723.1 NZ_CP066041:c668053-667799 [Streptococcus oralis]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFVGMGKPEPLKYDYQGAWSRRIDAENRLIYMIDGDSVAFLSF
KDHY

Nucleotide

• Length: 255 bp

>T183826 NZ_CP087187:4826129-4826383 [Pseudomonas atacamensis]
ATGAAAATCGAGTTCACGCCCACAGGCTGGGAAGACTATTTGTGGTTTCAGCAAAACGACAAGGCTGGGCTCAAGCGTAT
CAATCTTCTGATCAAAGCAATCAAGCGCGAACCGTTTGAGGGTGTCGGTAAACCAGAGGCGCTCAAACATAATATGAGCG
GCCTCTGGTCACGCCGAATAACGGCCGAACATCGTCTGGTGTACAGGGTTGAGGACGGCGAAATCTGCGTCATCAGTTGC
CGGTATCACTATTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9734.05 Da
• Isoelectric Point: 4.8430

>AT183826 WP_004181012.1 NZ_CP066041:c668311-668057 [Streptococcus oralis]
MEVVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Nucleotide

• Length: 255 bp

>AT183826 NZ_CP087187:4825878-4826132 [Pseudomonas atacamensis]
ATGCAAACCATCAACTACACCACCGCCCGTGCGCATTTGGCCGAGACGATGGACCGTGTCAATGAAGATCGTGCGCCGCT
ATTGGTCACTCGGCAGAAAGGTGAACCCGTAGTGATGATGTCTTTGGCCGAATACAACGCGTTGGAAGAAACAGCCTACT
TGCTTCGCTCCCCTGCCAACGCCGAAAGGCTGATGAAATCCATCGGTGAGTTGCGCGCCGGCAAAGCCAAAGTCAGGCAA
TTGATCGAAGAATGA

Structures

Toxin

• AlphaFold DB: A0A1X0WZT2