Detailed information of TA system TA183825

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-couple_hipB
• Location: 639047..639695
• Replicon: chromosome
• Accession: NZ_CP066041
• Organism: Streptococcus oralis strain FDAARGOS_1075

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: I6I32_RS03145
• Protein ID: WP_198465064.1
• Coordinates: 639330..639695 (-)
• Length: 122 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A1X0WZS6
• Locus tag: I6I32_RS03140
• Protein ID: WP_049504738.1
• Coordinates: 639047..639340 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6I32_RS03130	635508..636374	-	867	WP_198465063.1	methylenetetrahydrofolate reductase [NAD(P)H]	-
I6I32_RS03135	636445..638694	-	2250	WP_198464907.1	5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase	-
I6I32_RS03140	639047..639340	-	294	WP_049504738.1	helix-turn-helix transcriptional regulator	Antitoxin
I6I32_RS03145	639330..639695	-	366	WP_198465064.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I6I32_RS03150	639852..640217	-	366	WP_198464908.1	TIGR02328 family protein	-
I6I32_RS03155	640201..640605	-	405	WP_042903099.1	YbgA family protein	-
I6I32_RS03160	640659..642404	-	1746	WP_042902789.1	DUF2075 domain-containing protein	-
I6I32_RS03165	642404..642739	-	336	WP_042902790.1	nucleotide pyrophosphohydrolase	-
I6I32_RS03170	642862..643761	-	900	WP_180947331.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (36-110)

Antitoxin

• Cro/C1-type helix-turn-helix domain (37-88)

Sequences

Toxin

Protein

• Length: 122 a.a.
• Molecular weight: 14565.76 Da
• Isoelectric Point: 9.7755

>T183825 WP_198465064.1 NZ_CP066041:c639695-639330 [Streptococcus oralis]
VHTIYFYKDKNGNELVLDYMRELARKKSKDSRIKLNKLNDYIELLSQHGTRTGEPYIKHLEDEIWELRPLKDRILFVAWV
DGSFVLLHHFVKKTQKTPRREIDKAKRELKDIKERGLSDEE

Nucleotide

• Length: 366 bp

>T183825 NZ_CP087187:4825878-4826132 [Pseudomonas atacamensis]
ATGCAAACCATCAACTACACCACCGCCCGTGCGCATTTGGCCGAGACGATGGACCGTGTCAATGAAGATCGTGCGCCGCT
ATTGGTCACTCGGCAGAAAGGTGAACCCGTAGTGATGATGTCTTTGGCCGAATACAACGCGTTGGAAGAAACAGCCTACT
TGCTTCGCTCCCCTGCCAACGCCGAAAGGCTGATGAAATCCATCGGTGAGTTGCGCGCCGGCAAAGCCAAAGTCAGGCAA
TTGATCGAAGAATGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10722.39 Da
• Isoelectric Point: 5.1991

>AT183825 WP_049504738.1 NZ_CP066041:c639340-639047 [Streptococcus oralis]
MKNSAIGSNWKDIRSELFTKEEILESDMRVAIMSELIEARHEQGISQKKLEELSGVSQPVIARMETGKTSPQLDTVLKVL
ASLGKTLAVVPLEQEKG

Nucleotide

• Length: 294 bp

>AT183825 NZ_CP087187:4826129-4826383 [Pseudomonas atacamensis]
ATGAAAATCGAGTTCACGCCCACAGGCTGGGAAGACTATTTGTGGTTTCAGCAAAACGACAAGGCTGGGCTCAAGCGTAT
CAATCTTCTGATCAAAGCAATCAAGCGCGAACCGTTTGAGGGTGTCGGTAAACCAGAGGCGCTCAAACATAATATGAGCG
GCCTCTGGTCACGCCGAATAACGGCCGAACATCGTCTGGTGTACAGGGTTGAGGACGGCGAAATCTGCGTCATCAGTTGC
CGGTATCACTATTGA

Structures

Antitoxin

• AlphaFold DB: A0A1X0WZS6