Detailed information of TA system TA183808

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 3487626..3487997
• Replicon: chromosome
• Accession: NZ_CP066032
• Organism: Escherichia coli strain FDAARGOS_1059

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: Q8Z5Y6
• Locus tag: I6I16_RS17095
• Protein ID: WP_010989194.1
• Coordinates: 3487803..3487997 (-)
• Length: 65 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	3487626..3487804 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6I16_RS17055	3483068..3483724	-	657	WP_000011658.1	carbon-nitrogen hydrolase family protein	-
I6I16_RS17060	3483826..3484056	-	231	WP_000916763.1	DNA polymerase III subunit theta	-
I6I16_RS17065	3484195..3484569	+	375	WP_000204700.1	CopC domain-containing protein YobA	-
I6I16_RS17070	3484573..3485445	+	873	WP_000879280.1	copper homeostasis membrane protein CopD	-
I6I16_RS17075	3485458..3485799	+	342	WP_000976472.1	YebY family protein	-
I6I16_RS17080	3486192..3487268	-	1077	WP_001189084.1	phage integrase Arm DNA-binding domain-containing protein	-
I6I16_RS17085	3487234..3487515	-	282	WP_001311878.1	excisionase	-
I6I16_RS17090	3487622..3487810	-	189	WP_001356607.1	DUF1187 family protein	-
-	3487626..3487804	+	179	NuclAT_0	-	Antitoxin
-	3487626..3487804	+	179	NuclAT_0	-	Antitoxin
-	3487626..3487804	+	179	NuclAT_0	-	Antitoxin
-	3487626..3487804	+	179	NuclAT_0	-	Antitoxin
I6I16_RS17095	3487803..3487997	-	195	WP_010989194.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
I6I16_RS17100	3488061..3489113	-	1053	WP_001004417.1	recombinase RecT	-
I6I16_RS17105	3489125..3492268	-	3144	WP_000102207.1	exodeoxyribonuclease VIII	-
I6I16_RS17110	3492369..3492644	-	276	WP_001419882.1	hypothetical protein	-
I6I16_RS17115	3492719..3492889	-	171	WP_001436857.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3463808..3543955	80147

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-54)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7077.01 Da
• Isoelectric Point: 9.2886

>T183808 WP_010989194.1 NZ_CP066032:c3487997-3487803 [Escherichia coli]
MRYEKVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYSGSEKEALERWNKRTTGNNNGGVHV

Nucleotide

• Length: 195 bp

>T183808 NZ_CP087185:4803295-4803666 [Pseudomonas sichuanensis]
ATGGAAGCGATCAAGAATGTCAAACGCCTGTTCTGGGTTGGTAGCTCCCGAAAGGATATCCAGGCACTCCCGGCTGATGT
CCAAGATGTGTTCGGTTTTGCTCTGTATCAGGCTCAGGAAGGCGGCAAGCACTGGCAGGCAAAGGTGCTTAAAGGGTTTT
CAGGCGGCGGCGTGCTCGAGGTGGTCGAAGACCATCACGGCGACACCTATCGTGCGGTCTACACCATCAGCCTGGTCGAC
GCGGTTTACGTGCTGCACTGTTTCCAGCAGAAATCCCGCAGCGGCATCAAAACCTCAAGGCATGACGTGGATTTGATTCA
TGCCCGCCTGAAACTGGCACAGGCTCACTCGAAGGGGAAAACACATGATTGA

Antitoxin

Nucleotide

• Length: 179 bp

>AT183808 NZ_CP066032:3487626-3487804 [Escherichia coli]
GAGGACAGAAGTTTCTCGCAATTAAAATTTATCAGCTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTCCCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAATTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCAGTAATTTT

Structures

Toxin

• AlphaFold DB: A0A716R3V7

Antitoxin